Seroatlas · Human Serome Atlas

DUSP18

Dual specificity protein phosphatase 18

Also known as: DUS18_HUMAN, DUSP20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEJ0
Gene
DUSP18
Ensembl
ENSG00000167065
Chromosome
22
Canonical length
188 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q8NEJ0|DUSP18
     1  MTAPSCAFPV QFRQPSVSGL SQITKSLYIS NGVAANNKLM LSSNQITMVI NVSVEVVNTL
    61  YEDIQYMQVP VADSPNSRLC DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM
   121  KYHAMSLLDA HTWTKSCRPI IRPNSGFWEQ LIHYEFQLFG KNTVHMVSSP VGMIPDIYEK
   181  EVRLMIPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • fallopian tube: 10 nTPM
  • choroid plexus: 7.1 nTPM
  • rectum: 6.4 nTPM
  • lung: 5.2 nTPM
  • colon: 5.1 nTPM

Single-cell type

  • late spermatids: 644 nCPM
  • alveolar cells type 1: 226 nCPM
  • respiratory ciliated cells: 173 nCPM
  • early spermatids: 144 nCPM
  • late primary spermatocytes: 120 nCPM
  • ependymal cells: 112 nCPM

Immune cell

  • neutrophil: 32 nTPM
  • basophil: 32 nTPM
  • eosinophil: 30 nTPM
  • non-classical monocyte: 22 nTPM
  • intermediate monocyte: 19 nTPM
  • myeloid DC: 17 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • midbrain: 22 nTPM
  • medulla oblongata: 18 nTPM
  • white matter: 17 nTPM
  • spinal cord: 16 nTPM
  • pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0.12
gnomAD missense Z
0.11
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP18 as an antibody target. Whether an autoantibody or antibody against DUSP18 could matter depends on whether native DUSP18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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