Seroatlas · Human Serome Atlas

AMOTL2

Angiomotin-like protein 2

Also known as: AMOL2_HUMAN, LCCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2J4
Gene
AMOTL2
Ensembl
ENSG00000114019
Chromosome
3
Canonical length
779 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cell Junctions

OverviewNCBI Gene

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

779 residues, UniProt reviewed canonical sequence.

>Q9Y2J4|AMOTL2
     1  MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP
    61  EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ
   121  QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS
   181  SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ
   241  HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ
   301  ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE
   361  SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV
   421  AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ
   481  AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS
   541  PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR
   601  HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG
   661  SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TDRAPTEEPV VTAPPAAHAK
   721  HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG CSSSQRAASL DSVATSRVQD LSDMVEILI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMOTL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 71 nTPM
  • blood vessel: 51 nTPM
  • breast: 50 nTPM
  • endometrium: 37 nTPM
  • skin: 35 nTPM
  • esophagus: 32 nTPM

Single-cell type

  • podocytes: 86 nCPM
  • adipocytes: 54 nCPM
  • proximal tubule cells: 30 nCPM
  • loop of henle epithelial cells: 26 nCPM
  • endometrial secretory cells: 24 nCPM
  • cardiomyocytes: 23 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 160 nTPM
  • basal ganglia: 107 nTPM
  • medulla oblongata: 106 nTPM
  • cerebral cortex: 101 nTPM
  • thalamus: 95 nTPM
  • midbrain: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.16
gnomAD missense Z
0.08
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AMOTL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMOTL2 as an antibody target. Whether an autoantibody or antibody against AMOTL2 could matter depends on whether native AMOTL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMOTL2 is annotated at the cell surface, where native AMOTL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AMOTL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMOTL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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