Seroatlas · Human Serome Atlas

TRAF3

TNF receptor-associated factor 3

Also known as: CAP-1, CD40bp, CRAF1, LAP1, RNF118, TRAF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13114
Gene
TRAF3
Ensembl
ENSG00000131323
Chromosome
14
Canonical length
568 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q13114|TRAF3
     1  MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL
    61  CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE
   121  SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC
   181  KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV
   241  FQGTNQQIKA HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI
   301  EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM KSSVESLQNR
   361  VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA DMDLRFQVLE TASYNGVLIW
   421  KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF GYKMCARVYL NGDGMGKGTH LSLFFVIMRG
   481  EYDALLPWPF KQKVTLMLMD QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ
   541  TVLENGTYIK DDTIFIKVIV DTSDLPDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 18 nTPM
  • lymph node: 17 nTPM
  • appendix: 15 nTPM
  • cerebral cortex: 12 nTPM
  • tonsil: 12 nTPM
  • hippocampal formation: 12 nTPM

Single-cell type

  • neutrophils: 582 nCPM
  • plasma cells: 528 nCPM
  • b-cells: 397 nCPM
  • monocytes: 323 nCPM
  • neutrophil progenitors: 312 nCPM
  • pdcs: 284 nCPM

Immune cell

  • memory B-cell: 9.6 nTPM
  • naive B-cell: 9.6 nTPM
  • plasmacytoid DC: 5.1 nTPM
  • classical monocyte: 4.7 nTPM
  • memory CD4 T-cell: 3.9 nTPM
  • total PBMC: 3.9 nTPM

Brain region

  • hippocampal formation: 42 nTPM
  • cerebral cortex: 39 nTPM
  • hypothalamus: 35 nTPM
  • midbrain: 31 nTPM
  • medulla oblongata: 30 nTPM
  • pons: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAF3.

Disease | AllUniProt

Conditions TRAF3 is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 457 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 132b
  • TRAF3 haploinsufficiency
  • Herpes simplex encephalitis, susceptibility to, 3
  • TRAF3-related disorder
  • Autosomal dominant TRAF3-related disorders

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
2.99
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF3 as an antibody target. Whether an autoantibody or antibody against TRAF3 could matter depends on whether native TRAF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...