Seroatlas · Human Serome Atlas

EEF1G

Elongation factor 1-gamma

Also known as: EF1G, EF1G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26641
Gene
EEF1G
Ensembl
ENSG00000254772
Chromosome
11
Canonical length
437 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>P26641|EEF1G
     1  MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA
    61  FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI
   121  MHHNKQATEN AKEEVRRILG LLDAYLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF
   181  RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE
   241  KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE
   301  DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV
   361  ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE
   421  GAFQHVGKAF NQGKIFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
4,507 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 4,507 nTPM
  • tongue: 2,830 nTPM
  • ovary: 2,545 nTPM
  • skin: 2,252 nTPM
  • pancreas: 2,067 nTPM
  • tonsil: 1,828 nTPM

Single-cell type

  • enteric stem cells: 89 nCPM
  • enteric transient amplifying cells: 70 nCPM
  • paneth cells: 58 nCPM
  • other brain neurons: 57 nCPM
  • epididymal basal cells: 49 nCPM
  • enterocytes: 39 nCPM

Immune cell

  • total PBMC: 11,087 nTPM
  • naive CD4 T-cell: 6,137 nTPM
  • memory B-cell: 5,420 nTPM
  • naive B-cell: 5,104 nTPM
  • MAIT T-cell: 4,340 nTPM
  • naive CD8 T-cell: 4,201 nTPM

Brain region

  • hypothalamus: 454 nTPM
  • spinal cord: 453 nTPM
  • medulla oblongata: 431 nTPM
  • white matter: 418 nTPM
  • midbrain: 391 nTPM
  • basal ganglia: 384 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.5
DepMap mean gene effect
-1.02
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EEF1G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEF1G as an antibody target. Whether an autoantibody or antibody against EEF1G could matter depends on whether native EEF1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEF1G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EEF1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EEF1G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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