Seroatlas · Human Serome Atlas

ILF2

Interleukin enhancer-binding factor 2

Also known as: ILF2_HUMAN, NF45

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12905
Gene
ILF2
Ensembl
ENSG00000143621
Chromosome
1
Canonical length
390 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q12905|ILF2
     1  MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR
    61  NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA
   121  DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV
   181  PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL
   241  TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT
   301  VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI VTPSEKAYEK
   361  PPEKKEGEEE EENTEEPPQG EEEESMETQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ILF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
177 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 177 nTPM
  • bone marrow: 149 nTPM
  • tonsil: 124 nTPM
  • urinary bladder: 99 nTPM
  • skeletal muscle: 96 nTPM
  • parathyroid gland: 96 nTPM

Single-cell type

  • late primary spermatocytes: 392 nCPM
  • extravillous trophoblasts: 308 nCPM
  • syncytiotrophoblasts: 307 nCPM
  • migrating cytotrophoblasts: 283 nCPM
  • early primary spermatocytes: 283 nCPM
  • esophageal basal cells: 273 nCPM

Immune cell

  • total PBMC: 357 nTPM
  • myeloid DC: 219 nTPM
  • NK-cell: 219 nTPM
  • T-reg: 213 nTPM
  • plasmacytoid DC: 213 nTPM
  • memory B-cell: 200 nTPM

Brain region

  • choroid plexus: 63 nTPM
  • white matter: 59 nTPM
  • hypothalamus: 56 nTPM
  • spinal cord: 54 nTPM
  • pons: 53 nTPM
  • cerebellum: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
3.4
DepMap mean gene effect
-1.05
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ILF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ILF2 as an antibody target. Whether an autoantibody or antibody against ILF2 could matter depends on whether native ILF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ILF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ILF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ILF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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