Seroatlas · Human Serome Atlas

NAP1L1

Nucleosome assembly protein 1-like 1

Also known as: MGC23410, MGC8688, NAP1, NAP1L, NP1L1_HUMAN, NRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55209
Gene
NAP1L1
Ensembl
ENSG00000187109
Chromosome
12
Canonical length
391 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>P55209|NAP1L1
     1  MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA ALQERLDGLV
    61  ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH DLERKYAVLY QPLFDKRFEI
   121  INAIYEPTEE ECEWKPDEED EISEELKEKA KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL
   181  LSDMVQEHDE PILKHLKDIK VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD
   241  DSDPFSFDGP EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF
   301  FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD DDDYDEEGEE
   361  ADEEGEEEGD EENDPDYDPK KDQNPAECKQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAP1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
607 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 607 nTPM
  • spinal cord: 447 nTPM
  • lymph node: 426 nTPM
  • skeletal muscle: 418 nTPM
  • tonsil: 362 nTPM
  • cervix: 352 nTPM

Single-cell type

  • platelets: 4,031 nCPM
  • megakaryocytes: 927 nCPM
  • decidual stromal cells: 898 nCPM
  • ovarian stromal cells: 867 nCPM
  • esophageal basal cells: 808 nCPM
  • peritubular myoid cells: 745 nCPM

Immune cell

  • non-classical monocyte: 736 nTPM
  • intermediate monocyte: 350 nTPM
  • naive CD4 T-cell: 252 nTPM
  • memory B-cell: 249 nTPM
  • T-reg: 243 nTPM
  • myeloid DC: 227 nTPM

Brain region

  • spinal cord: 393 nTPM
  • white matter: 353 nTPM
  • thalamus: 328 nTPM
  • basal ganglia: 327 nTPM
  • medulla oblongata: 324 nTPM
  • pons: 294 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
1.76
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAP1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAP1L1 as an antibody target. Whether an autoantibody or antibody against NAP1L1 could matter depends on whether native NAP1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAP1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAP1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAP1L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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