Seroatlas · Human Serome Atlas

RRP1B

Ribosomal RNA processing protein 1 homolog B

Also known as: KIAA0179, Nnp1, PPP1R136, RRP1, RRP1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14684
Gene: RRP1B
Ensembl: ENSG00000160208
Chromosome: 21
Canonical length: 758 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in cellular response to virus; positive regulation of apoptotic process; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

758 residues, UniProt reviewed canonical sequence.

>Q14684|RRP1B
     1  MAPAMQPAEI QFAQRLASSE KGIRDRAVKK LRQYISVKTQ RETGGFSQEE LLKIWKGLFY
    61  CMWVQDEPLL QEELANTIAQ LVHAVNNSAA QHLFIQTFWQ TMNREWKGID RLRLDKYYML
   121  IRLVLRQSFE VLKRNGWEES RIKVFLDVLM KEVLCPESQS PNGVRFHFID IYLDELSKVG
   181  GKELLADQNL KFIDPFCKIA AKTKDHTLVQ TIARGVFEAI VDQSPFVPEE TMEEQKTKVG
   241  DGDLSAEEIP ENEVSLRRAV SKKKTALGKN HSRKDGLSDE RGRDDCGTFE DTGPLLQFDY
   301  KAVADRLLEM TSRKNTPHFN RKRLSKLIKK FQDLSEGSSI SQLSFAEDIS ADEDDQILSQ
   361  GKHKKKGNKL LEKTNLEKEK GSRVFCVEEE DSESSLQKRR RKKKKKHHLQ PENPGPGGAA
   421  PSLEQNRGRE PEASGLKALK ARVAEPGAEA TSSTGEESGS EHPPAVPMHN KRKRPRKKSP
   481  RAHREMLESA VLPPEDMSQS GPSGSHPQGP RGSPTGGAQL LKRKRKLGVV PVNGSGLSTP
   541  AWPPLQQEGP PTGPAEGANS HTTLPQRRRL QKKKAGPGSL ELCGLPSQKT ASLKKRKKMR
   601  VMSNLVEHNG VLESEAGQPQ ALGSSGTCSS LKKQKLRAES DFVKFDTPFL PKPLFFRRAK
   661  SSTATHPPGP AVQLNKTPSS SKKVTFGLNR NMTAEFKKTD KSILVSPTGP SRVAFDPEQK
   721  PLHGVLKTPT SSPASSPLVA KKPLTTTPRR RPRAMDFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

retina: 26 nTPM
lymph node: 16 nTPM
thymus: 15 nTPM
tonsil: 14 nTPM
appendix: 12 nTPM
skeletal muscle: 11 nTPM

Single-cell type

late spermatids: 584 nCPM
early spermatids: 371 nCPM
rod photoreceptor cells: 306 nCPM
cone photoreceptor cells: 186 nCPM
late primary spermatocytes: 94 nCPM
differentiating spermatogonia: 66 nCPM

Immune cell

naive CD8 T-cell: 8.6 nTPM
memory CD4 T-cell: 7.9 nTPM
memory CD8 T-cell: 7.5 nTPM
MAIT T-cell: 7.3 nTPM
naive CD4 T-cell: 7.3 nTPM
T-reg: 6.6 nTPM

Brain region

basal ganglia: 16 nTPM
white matter: 15 nTPM
medulla oblongata: 14 nTPM
thalamus: 14 nTPM
midbrain: 14 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP1B as an antibody target. Whether an autoantibody or antibody against RRP1B could matter depends on whether native RRP1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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