PDCD4

Protein identityUniProt · HPA

UniProt accession

Q53EL6

Gene

PDCD4

Ensembl

ENSG00000150593

Chromosome

10

Canonical length

469 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q53EL6|PDCD4
     1  MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK
    61  RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG
   121  KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD
   181  TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF
   241  DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV
   301  LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH
   361  HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP
   421  HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

477 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.93

gnomAD pLI

0

gnomAD missense Z

0.22

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• BMP signaling pathway
• cellular response to lipopolysaccharide
• epithelial to mesenchymal transition involved in cardiac fibroblast development
• negative regulation of cytokine production involved in inflammatory response
• negative regulation of DNA-templated transcription
• negative regulation of JUN kinase activity
• negative regulation of myofibroblast differentiation
• negative regulation of vascular associated smooth muscle cell differentiation
• negative regulation of vascular associated smooth muscle cell proliferation
• positive regulation of endothelial cell apoptotic process
• positive regulation of inflammatory response
• positive regulation of non-canonical NF-kappaB signal transduction
• positive regulation of vascular associated smooth muscle cell apoptotic process

Molecular functions

• RNA binding

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Initiation factor eIF-4 gamma, MA3
• Armadillo-type fold
• MA3 domain
• Programmed cell death protein 4

KeywordsUniProt

• Acetylation
• Apoptosis
• Cytoplasm
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Tumor suppressor
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PDCD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BTRC
• EIF4G1
• FBXW11
• EIF4A1
• APOE
• EIF4A2
• EIF4A3
• PSEN2
• RPL5
• RPS13