Seroatlas · Human Serome Atlas

LIN28A

Protein lin-28 homolog A

Also known as: CSDD1, FLJ12457, LIN-28, LIN28, LN28A_HUMAN, ZCCHC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9Z2
Gene
LIN28A
Ensembl
ENSG00000131914
Chromosome
1
Canonical length
209 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol,Rods & Rings

OverviewNCBI Gene

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q9H9Z2|LIN28A
     1  MGSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR MGFGFLSMTA
    61  RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS AKGLESIRVT GPGGVFCIGS
   121  ERRPKGKSMQ KRRSKGDRCY NCGGLDHHAK ECKLPPQPKK CHFCQSISHM VASCPLKAQQ
   181  GPSAQGKPTY FREEEEEIHS PTLLPEAQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN28A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
4.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.9 nTPM
  • retina: 0.3 nTPM
  • bone marrow: 0.2 nTPM
  • skeletal muscle: 0.2 nTPM
  • duodenum: 0.1 nTPM
  • epididymis: 0.1 nTPM

Single-cell type

  • late spermatids: 111 nCPM
  • early spermatids: 27 nCPM
  • late primary spermatocytes: 25 nCPM
  • epicardial cells: 2.3 nCPM
  • gastric chief cells: 1.1 nCPM
  • rod photoreceptor cells: 0.9 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • cerebellum: 5.6 nTPM
  • white matter: 4.5 nTPM
  • choroid plexus: 4.4 nTPM
  • thalamus: 4.3 nTPM
  • cerebral cortex: 4.1 nTPM
  • midbrain: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.02
gnomAD missense Z
0.71
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIN28A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN28A as an antibody target. Whether an autoantibody or antibody against LIN28A could matter depends on whether native LIN28A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN28A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIN28A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIN28A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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