Seroatlas · Human Serome Atlas

MAK16

Protein MAK16 homolog

Also known as: MAK16_HUMAN, MAK16L, RBM13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXY0
Gene: MAK16
Ensembl: ENSG00000198042
Chromosome: 8
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Vesicles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q9BXY0|MAK16
     1  MQSDDVIWDT LGNKQFCSFK IRTKTQSFCR NEYSLTGLCN RSSCPLANSQ YATIKEEKGQ
    61  CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY WPRFIRHKCK QRFTKITQYL
   121  IRIRKLTLKR QRKLVPLSKK VERREKRREE KALIAAQLDN AIEKELLERL KQDTYGDIYN
   181  FPIHAFDKAL EQQEAESDSS DTEEKDDDDD DEEDVGKREF VEDGEVDESD ISDFEDMDKL
   241  DASSDEDQDG KSSSEEEEEK ALSAKHKGKM PLRGPLQRKR AYVEIEYEQE TEPVAKAKTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAK16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 11 nTPM
lymph node: 10 nTPM
tonsil: 10 nTPM
adipose tissue: 9.3 nTPM
skeletal muscle: 8.9 nTPM
appendix: 8.8 nTPM

Single-cell type

cardiomyocytes: 54 nCPM
erythrocyte progenitors: 30 nCPM
megakaryocyte progenitors: 29 nCPM
pancreatic acinar cells: 28 nCPM
esophageal basal cells: 26 nCPM
differentiating spermatogonia: 24 nCPM

Immune cell

non-classical monocyte: 7.9 nTPM
intermediate monocyte: 5 nTPM
NK-cell: 4.5 nTPM
naive CD8 T-cell: 4.3 nTPM
naive CD4 T-cell: 4 nTPM
MAIT T-cell: 3.6 nTPM

Brain region

hypothalamus: 13 nTPM
midbrain: 13 nTPM
white matter: 12 nTPM
pons: 11 nTPM
spinal cord: 10 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 0.58
DepMap mean gene effect: -1.8
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosomal eL28/Mak16
Ribosomal L28e protein family
Mak16 protein
Mak16 protein C-terminal region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAK16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RPL31

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAK16 as an antibody target. Whether an autoantibody or antibody against MAK16 could matter depends on whether native MAK16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAK16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAK16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...