Seroatlas · Human Serome Atlas

PINX1

PIN2/TERF1-interacting telomerase inhibitor 1

Also known as: FLJ20565, Gno1, LPTL, LPTS, MGC8850, PINX1_HUMAN, Pxr1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BK5
Gene
PINX1
Ensembl
ENSG00000254093
Chromosome
8
Canonical length
328 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Enables telomerase RNA binding activity and telomerase inhibitor activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q96BK5|PINX1
     1  MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEQ GATDHIKVQV
    61  KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS
   121  KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE
   181  YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKRNKEAT GKDVESYLQP KAKRHTEGKP
   241  ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK
   301  KLQKPVEIAE DATLEETLVK KKKKKDSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PINX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • skin: 14 nTPM
  • skeletal muscle: 13 nTPM
  • thymus: 12 nTPM
  • esophagus: 12 nTPM
  • liver: 11 nTPM
  • retina: 11 nTPM

Single-cell type

  • late spermatids: 29 nCPM
  • early spermatids: 22 nCPM
  • late primary spermatocytes: 20 nCPM
  • syncytiotrophoblasts: 6.5 nCPM
  • basal keratinocytes: 6 nCPM
  • differentiating spermatogonia: 6 nCPM

Immune cell

  • MAIT T-cell: 19 nTPM
  • naive CD4 T-cell: 17 nTPM
  • T-reg: 16 nTPM
  • memory CD8 T-cell: 16 nTPM
  • gdT-cell: 15 nTPM
  • naive CD8 T-cell: 14 nTPM

Brain region

  • cerebellum: 12 nTPM
  • cerebral cortex: 12 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 9.2 nTPM
  • thalamus: 9.1 nTPM
  • pons: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0
gnomAD missense Z
-2.59
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PINX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PINX1 as an antibody target. Whether an autoantibody or antibody against PINX1 could matter depends on whether native PINX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PINX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PINX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PINX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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