Seroatlas · Human Serome Atlas

NOP14

Nucleolar protein 14

Also known as: C4orf9, NOL14, NOP14_HUMAN, RES4-25, UTP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78316
Gene: NOP14
Ensembl: ENSG00000087269
Chromosome: 4
Canonical length: 857 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

857 residues, UniProt reviewed canonical sequence.

>P78316|NOP14
     1  MAKAKKVGAR RKASGAPAGA RGGPAKANSN PFEVKVNRQK FQILGRKTRH DVGLPGVSRA
    61  RALRKRTQTL LKEYKERDKS NVFRDKRFGE YNSNMSPEEK MMKRFALEQQ RHHEKKSIYN
   121  LNEDEELTHY GQSLADIEKH NDIVDSDSDA EDRGTLSAEL TAAHFGGGGG LLHKKTQQEG
   181  EEREKPKSRK ELIEELIAKS KQEKRERQAQ REDALELTEK LDQDWKEIQT LLSHKTPKSE
   241  NRDKKEKPKP DAYDMMVREL GFEMKAQPSN RMKTEAELAK EEQEHLRKLE AERLRRMLGK
   301  DEDENVKKPK HMSADDLNDG FVLDKDDRRL LSYKDGKMNV EEDVQEEQSK EASDPESNEE
   361  EGDSSGGEDT EESDSPDSHL DLESNVESEE ENEKPAKEQR QTPGKGLISG KERAGKATRD
   421  ELPYTFAAPE SYEELRSLLL GRSMEEQLLV VERIQKCNHP SLAEGNKAKL EKLFGFLLEY
   481  VGDLATDDPP DLTVIDKLVV HLYHLCQMFP ESASDAIKFV LRDAMHEMEE MIETKGRAAL
   541  PGLDVLIYLK ITGLLFPTSD FWHPVVTPAL VCLSQLLTKC PILSLQDVVK GLFVCCLFLE
   601  YVALSQRFIP ELINFLLGIL YIATPNKASQ GSTLVHPFRA LGKNSELLVV SAREDVATWQ
   661  QSSLSLRWAS RLRAPTSTEA NHIRLSCLAV GLALLKRCVL MYGSLPSFHA IMGPLQALLT
   721  DHLADCSHPQ ELQELCQSTL TEMESQKQLC RPLTCEKSKP VPLKLFTPRL VKVLEFGRKQ
   781  GSSKEEQERK RLIHKHKREF KGAVREIRKD NQFLARMQLS EIMERDAERK RKVKQLFNSL
   841  ATQEGEWKAL KRKKFKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 39 nTPM
pancreas: 23 nTPM
lymph node: 22 nTPM
bone marrow: 22 nTPM
skin: 21 nTPM
tonsil: 18 nTPM

Single-cell type

erythrocyte progenitors: 106 nCPM
megakaryocyte progenitors: 75 nCPM
megakaryocyte-erythroid progenitors: 74 nCPM
urothelial cells: 62 nCPM
epicardial cells: 61 nCPM
thymic myoid cells: 54 nCPM

Immune cell

MAIT T-cell: 4.9 nTPM
memory CD8 T-cell: 4.2 nTPM
naive CD4 T-cell: 4.1 nTPM
naive B-cell: 3.5 nTPM
memory CD4 T-cell: 3.4 nTPM
NK-cell: 3.2 nTPM

Brain region

cerebellum: 29 nTPM
choroid plexus: 20 nTPM
thalamus: 19 nTPM
white matter: 18 nTPM
medulla oblongata: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: -1.06
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleolar protein 14
Nop14-like family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOP14 as an antibody target. Whether an autoantibody or antibody against NOP14 could matter depends on whether native NOP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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