Seroatlas · Human Serome Atlas

UBE2K

Ubiquitin-conjugating enzyme E2 K

Also known as: HIP2, HYPG, UBC1, UBE2K_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61086
Gene
UBE2K
Ensembl
ENSG00000078140
Chromosome
4
Canonical length
200 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>P61086|UBE2K
     1  MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI
    61  KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA
   121  EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI
   181  VALSSKSWDV ETATELLLSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • liver: 42 nTPM
  • cerebral cortex: 38 nTPM
  • skeletal muscle: 35 nTPM
  • colon: 34 nTPM
  • stomach: 30 nTPM
  • duodenum: 29 nTPM

Single-cell type

  • esophageal apical cells: 495 nCPM
  • myonuclei: 391 nCPM
  • extravillous trophoblasts: 359 nCPM
  • erythrocyte progenitors: 345 nCPM
  • neutrophil progenitors: 337 nCPM
  • late spermatids: 323 nCPM

Immune cell

  • plasmacytoid DC: 28 nTPM
  • non-classical monocyte: 26 nTPM
  • eosinophil: 25 nTPM
  • memory B-cell: 21 nTPM
  • basophil: 20 nTPM
  • myeloid DC: 20 nTPM

Brain region

  • cerebral cortex: 73 nTPM
  • cerebellum: 62 nTPM
  • basal ganglia: 54 nTPM
  • hippocampal formation: 51 nTPM
  • white matter: 50 nTPM
  • hypothalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
3.23
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2K as an antibody target. Whether an autoantibody or antibody against UBE2K could matter depends on whether native UBE2K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2K. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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