Seroatlas · Human Serome Atlas

UBE2D3

Ubiquitin-conjugating enzyme E2 D3

Also known as: UB2D3_HUMAN, UbcH5C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61077
Gene
UBE2D3
Ensembl
ENSG00000109332
Chromosome
4
Canonical length
147 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P61077|UBE2D3
     1  MALKRINKEL SDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY
    61  PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV
   121  PEIARIYKTD RDKYNRISRE WTQKYAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
452 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 452 nTPM
  • liver: 235 nTPM
  • skeletal muscle: 230 nTPM
  • tongue: 185 nTPM
  • thymus: 185 nTPM
  • tonsil: 184 nTPM

Single-cell type

  • neutrophils: 1,721 nCPM
  • esophageal apical cells: 1,698 nCPM
  • oocytes: 1,156 nCPM
  • late spermatids: 891 nCPM
  • early spermatids: 880 nCPM
  • syncytiotrophoblasts: 837 nCPM

Immune cell

  • neutrophil: 823 nTPM
  • basophil: 617 nTPM
  • total PBMC: 423 nTPM
  • eosinophil: 395 nTPM
  • non-classical monocyte: 273 nTPM
  • intermediate monocyte: 256 nTPM

Brain region

  • cerebral cortex: 200 nTPM
  • white matter: 199 nTPM
  • hypothalamus: 189 nTPM
  • medulla oblongata: 187 nTPM
  • spinal cord: 181 nTPM
  • pons: 179 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE2D3.

Disease | ImmuneIEDB

Conditions an epitope on UBE2D3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.41
gnomAD missense Z
2.99
DepMap mean gene effect
-0.72
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2D3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2D3 as an antibody target. Whether an autoantibody or antibody against UBE2D3 could matter depends on whether native UBE2D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2D3 is annotated at the cell surface, where native UBE2D3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UBE2D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2D3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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