Seroatlas · Human Serome Atlas

L3MBTL3

Lethal(3)malignant brain tumor-like protein 3

Also known as: KIAA1798, LMBL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JM7
Gene
L3MBTL3
Ensembl
ENSG00000198945
Chromosome
6
Canonical length
780 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q96JM7|L3MBTL3
     1  MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDEN EMENVKKATA
    61  TTTWMVPTAQ EAPTSPPSSR PVFPPAYWTS PPGCPTVFSE KTGMPFRLKD PVKVEGLQFC
   121  ENCCQYGNVD ECLSGGNYCS QNCARHIKDK DQKEERDVEE DNEEEDPKCS RKKKPKLSLK
   181  ADTKEDGEER DDEMENKQDV RILRGSQRAR RKRRGDSAVL KQGLPPKGKK AWCWASYLEE
   241  EKAVAVPAKL FKEHQSFPYN KNGFKVGMKL EGVDPEHQSV YCVLTVAEVC GYRIKLHFDG
   301  YSDCYDFWVN ADALDIHPVG WCEKTGHKLH PPKGYKEEEF NWQTYLKTCK AQAAPKSLFE
   361  NQNITVIPSG FRVGMKLEAV DKKNPSFICV ATVTDMVDNR FLVHFDNWDE SYDYWCEASS
   421  PHIHPVGWCK EHRRTLITPP GYPNVKHFSW DKYLEETNSL PAPARAFKVK PPHGFQKKMK
   481  LEVVDKRNPM FIRVATVADT DDHRVKVHFD GWNNCYDYWI DADSPDIHPV GWCSKTGHPL
   541  QPPLSPLELM EASEHGGCST PGCKGIGHFK RARHLGPHSA ANCPYSEINL NKDRIFPDRL
   601  SGEMPPASPS FPRNKRTDAN ESSSSPEIRD QHADDVKEDF EERTESEMRT SHEARGAREE
   661  PTVQQAQRRS AVFLSFKSPI PCLPLRWEQQ SKLLPTVAGI PASKVSKWST DEVSEFIQSL
   721  PGCEEHGKVF KDEQIDGEAF LLMTQTDIVK IMSIKLGPAL KIFNSILMFK AAEKNSHNEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against L3MBTL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 12 nTPM
  • epididymis: 11 nTPM
  • endometrium: 11 nTPM
  • adrenal gland: 10 nTPM
  • lymph node: 10 nTPM
  • appendix: 9.3 nTPM

Single-cell type

  • pituicytes/fscs: 235 nCPM
  • adrenal cortex cells: 117 nCPM
  • choroid plexus epithelial cells: 102 nCPM
  • b-cells: 91 nCPM
  • podocytes: 81 nCPM
  • thymocytes: 61 nCPM

Immune cell

  • non-classical monocyte: 23 nTPM
  • plasmacytoid DC: 15 nTPM
  • naive B-cell: 14 nTPM
  • memory B-cell: 11 nTPM
  • basophil: 8.3 nTPM
  • T-reg: 6 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • hypothalamus: 10 nTPM
  • hippocampal formation: 9.5 nTPM
  • cerebral cortex: 8.2 nTPM
  • amygdala: 7.7 nTPM
  • basal ganglia: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
1.64
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of L3MBTL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads L3MBTL3 as an antibody target. Whether an autoantibody or antibody against L3MBTL3 could matter depends on whether native L3MBTL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

L3MBTL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label L3MBTL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/L3MBTL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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