Seroatlas · Human Serome Atlas

UBE2E2

Ubiquitin-conjugating enzyme E2 E2

Also known as: FLJ25157, UB2E2_HUMAN, UbcH8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LR5
Gene
UBE2E2
Ensembl
ENSG00000182247
Chromosome
3
Canonical length
201 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q96LR5|UBE2E2
     1  MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI
    61  QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK
   121  VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ
   181  YMTNRAEHDR MARQWTKRYA T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 39 nTPM
  • cerebral cortex: 27 nTPM
  • epididymis: 24 nTPM
  • adipose tissue: 23 nTPM
  • ovary: 21 nTPM
  • hypothalamus: 20 nTPM

Single-cell type

  • myonuclei: 1,644 nCPM
  • microglia: 1,418 nCPM
  • adipocytes: 1,165 nCPM
  • gonadotrophs: 1,033 nCPM
  • thymic myoid cells: 965 nCPM
  • oligodendrocytes: 963 nCPM

Immune cell

  • plasmacytoid DC: 74 nTPM
  • myeloid DC: 58 nTPM
  • non-classical monocyte: 55 nTPM
  • intermediate monocyte: 51 nTPM
  • classical monocyte: 42 nTPM
  • naive B-cell: 40 nTPM

Brain region

  • white matter: 65 nTPM
  • cerebral cortex: 54 nTPM
  • hippocampal formation: 45 nTPM
  • basal ganglia: 43 nTPM
  • hypothalamus: 43 nTPM
  • cerebellum: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE2E2.

Disease | ImmuneIEDB

Conditions an epitope on UBE2E2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
2.29
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2E2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2E2 as an antibody target. Whether an autoantibody or antibody against UBE2E2 could matter depends on whether native UBE2E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2E2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2E2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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