Seroatlas · Human Serome Atlas

CBX8

Chromobox protein homolog 8

Also known as: CBX8_HUMAN, HPC3, PC3, RC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC52
Gene
CBX8
Ensembl
ENSG00000141570
Chromosome
17
Canonical length
389 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q9HC52|CBX8
     1  MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER
    61  EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR GIRIPYPGRS PQDLASTSRA
   121  REGLRNMGLS PPASSTSTSS TCRAEAPRDR DRDRDRDRER DRERERERER ERERERERER
   181  GTSRVDDKPS SPGDSSKKRG PKPRKELPDP SQRPLGEPSA GLGEYLKGRK LDDTPSGAGK
   241  FPAGHSVIQL ARRQDSDLVQ CGVTSPSSAE ATGKLAVDTF PARVIKHRAA FLEAKGQGAL
   301  DPNGTRVRHG SGPPSSGGGL YRDMGAQGGR PSLIARIPVA RILGDPEEES WSPSLTNLEK
   361  VVVTDVTSNF LTVTIKESNT DQGFFKEKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBX8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • epididymis: 10 nTPM
  • pituitary gland: 7 nTPM
  • parathyroid gland: 6.2 nTPM
  • liver: 5.3 nTPM
  • fallopian tube: 5 nTPM

Single-cell type

  • fallopian tube ciliated cells: 20 nCPM
  • differentiating spermatogonia: 17 nCPM
  • epididymal principal cells: 16 nCPM
  • endometrial ciliated cells: 16 nCPM
  • epididymal efferent duct ciliated cells: 12 nCPM
  • cholangiocytes: 11 nCPM

Immune cell

  • eosinophil: 15 nTPM
  • non-classical monocyte: 7.4 nTPM
  • intermediate monocyte: 6.8 nTPM
  • neutrophil: 6.3 nTPM
  • myeloid DC: 5.7 nTPM
  • classical monocyte: 5 nTPM

Brain region

  • white matter: 6.6 nTPM
  • thalamus: 5.8 nTPM
  • pons: 5.3 nTPM
  • medulla oblongata: 5.1 nTPM
  • hypothalamus: 5 nTPM
  • amygdala: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.99
gnomAD missense Z
0.94
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBX8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBX8 as an antibody target. Whether an autoantibody or antibody against CBX8 could matter depends on whether native CBX8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBX8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CBX8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CBX8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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