Seroatlas · Human Serome Atlas

UBE2D2

Ubiquitin-conjugating enzyme E2 D2

Also known as: UB2D2_HUMAN, UBC4, UbcH5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62837
Gene
UBE2D2
Ensembl
ENSG00000131508
Chromosome
5
Canonical length
147 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P62837|UBE2D2
     1  MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY
    61  PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV
   121  PEIARIYKTD REKYNRIARE WTQKYAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 78 nTPM
  • fallopian tube: 75 nTPM
  • testis: 68 nTPM
  • cervix: 62 nTPM
  • tonsil: 52 nTPM
  • spinal cord: 52 nTPM

Single-cell type

  • endometrial glandular cells: 2,919 nCPM
  • endometrial ciliated cells: 2,798 nCPM
  • endometrial luminal cells: 1,481 nCPM
  • fallopian tube ciliated cells: 867 nCPM
  • late primary spermatocytes: 809 nCPM
  • fallopian secretory cells: 792 nCPM

Immune cell

  • eosinophil: 58 nTPM
  • T-reg: 57 nTPM
  • neutrophil: 57 nTPM
  • naive B-cell: 56 nTPM
  • naive CD4 T-cell: 53 nTPM
  • plasmacytoid DC: 52 nTPM

Brain region

  • white matter: 83 nTPM
  • pons: 81 nTPM
  • midbrain: 79 nTPM
  • thalamus: 78 nTPM
  • hypothalamus: 77 nTPM
  • medulla oblongata: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.97
gnomAD missense Z
2.96
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2D2 as an antibody target. Whether an autoantibody or antibody against UBE2D2 could matter depends on whether native UBE2D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2D2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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