Seroatlas · Human Serome Atlas

DYNC1I2

Cytoplasmic dynein 1 intermediate chain 2

Also known as: DC1I2_HUMAN, DIC74, DNCI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13409
Gene
DYNC1I2
Ensembl
ENSG00000077380
Chromosome
2
Canonical length
638 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Centrosome,Cytosol,Flagellar centriole,Mid piece,Principal piece,End piece
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>Q13409|DYNC1I2
     1  MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA
    61  EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP
   121  SVLQLHSDSD LGRGPIKLGM AKITQVDFPP REIVTYTKET QTPVMAQPKE DEEEDDDVVA
   181  PKPPIEPEEE KTLKKDEEND SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ
   241  INIFFDYSGR DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN
   301  NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG GTYSGQIVLW
   361  DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS ISTDGKICSW SLDMLSHPQD
   421  SMELVHKQSK AVAVTSMSFP VGDVNNFVVG SEEGSVYTAC RHGSKAGISE MFEGHQGPIT
   481  GIHCHAAVGA VDFSHLFVTS SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF
   541  ACVDGMGRLD LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG
   601  EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNC1I2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
153 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 153 nTPM
  • midbrain: 92 nTPM
  • blood vessel: 87 nTPM
  • cerebral cortex: 81 nTPM
  • smooth muscle: 75 nTPM
  • kidney: 75 nTPM

Single-cell type

  • late primary spermatocytes: 318 nCPM
  • esophageal apical cells: 262 nCPM
  • oocytes: 230 nCPM
  • oligodendrocytes: 200 nCPM
  • early primary spermatocytes: 182 nCPM
  • hepatic stellate cells: 181 nCPM

Immune cell

  • basophil: 211 nTPM
  • plasmacytoid DC: 112 nTPM
  • non-classical monocyte: 101 nTPM
  • intermediate monocyte: 98 nTPM
  • classical monocyte: 94 nTPM
  • memory B-cell: 78 nTPM

Brain region

  • white matter: 225 nTPM
  • medulla oblongata: 181 nTPM
  • pons: 167 nTPM
  • cerebellum: 164 nTPM
  • basal ganglia: 157 nTPM
  • midbrain: 150 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DYNC1I2.

Disease | AllUniProt

Conditions DYNC1I2 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with microcephaly and structural brain anomalies (NEDMIBA) MIM:618492

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 122 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
2.45
DepMap mean gene effect
-1.64
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNC1I2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNC1I2 as an antibody target. Whether an autoantibody or antibody against DYNC1I2 could matter depends on whether native DYNC1I2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNC1I2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNC1I2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNC1I2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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