Seroatlas · Human Serome Atlas

UBE2E3

Ubiquitin-conjugating enzyme E2 E3

Also known as: UB2E3_HUMAN, UbcH9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969T4
Gene
UBE2E3
Ensembl
ENSG00000170035
Chromosome
2
Canonical length
207 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q969T4|UBE2E3
     1  MSSDRQRSDD ESPSTSSGSS DADQRDPAAP EPEEQEERKP SATQQKKNTK LSSKTTAKLS
    61  TSAKRIQKEL AEITLDPPPN CSAGPKGDNI YEWRSTILGP PGSVYEGGVF FLDITFSSDY
   121  PFKPPKVTFR TRIYHCNINS QGVICLDILK DNWSPALTIS KVLLSICSLL TDCNPADPLV
   181  GSIATQYLTN RAEHDRIARQ WTKRYAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2E3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
164 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 164 nTPM
  • tongue: 83 nTPM
  • cerebral cortex: 81 nTPM
  • hippocampal formation: 76 nTPM
  • parathyroid gland: 75 nTPM
  • thyroid gland: 69 nTPM

Single-cell type

  • sertoli cells: 356 nCPM
  • megakaryocytes: 278 nCPM
  • platelets: 258 nCPM
  • prostatic glandular cells: 255 nCPM
  • differentiating spermatogonia: 249 nCPM
  • oligodendrocyte progenitor cells: 244 nCPM

Immune cell

  • plasmacytoid DC: 60 nTPM
  • eosinophil: 54 nTPM
  • non-classical monocyte: 37 nTPM
  • basophil: 29 nTPM
  • classical monocyte: 28 nTPM
  • neutrophil: 26 nTPM

Brain region

  • hippocampal formation: 98 nTPM
  • cerebral cortex: 83 nTPM
  • white matter: 76 nTPM
  • spinal cord: 74 nTPM
  • basal ganglia: 69 nTPM
  • hypothalamus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.43
gnomAD missense Z
2.75
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2E3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2E3 as an antibody target. Whether an autoantibody or antibody against UBE2E3 could matter depends on whether native UBE2E3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2E3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2E3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2E3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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