Seroatlas · Human Serome Atlas

SPATA24

Spermatogenesis-associated protein 24

Also known as: CCDC161, SPA24_HUMAN, T6441

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86W54
Gene: SPATA24
Ensembl: ENSG00000170469
Chromosome: 5
Canonical length: 205 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q86W54|SPATA24
     1  MATPLGWSKA GSGSVCLALD QLRDVIESQE ELIHQLRNVM VLQDENFVSK EEFQAVEKKL
    61  VEEKAAHAKT KVLLAKEEEK LQFALGEVEV LSKQLEKEKL AFEKALSSVK SKVLQESSKK
   121  DQLITKCNEI ESHIIKQEDI LNGKENEIKE LQQVISQQKQ IFRNHMSDFR IQKQQESYMA
   181  QVLDQKHKKA SGTRQARSHQ HPREK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

testis: 139 nTPM
skeletal muscle: 22 nTPM
epididymis: 20 nTPM
heart muscle: 19 nTPM
tongue: 18 nTPM
fallopian tube: 14 nTPM

Single-cell type

late spermatids: 3,995 nCPM
early spermatids: 1,279 nCPM
late primary spermatocytes: 323 nCPM
respiratory ciliated cells: 35 nCPM
fallopian tube ciliated cells: 29 nCPM
early primary spermatocytes: 29 nCPM

Immune cell

naive CD8 T-cell: 4.8 nTPM
MAIT T-cell: 4.1 nTPM
memory B-cell: 3.5 nTPM
memory CD8 T-cell: 3.5 nTPM
naive CD4 T-cell: 3.4 nTPM
memory CD4 T-cell: 3.1 nTPM

Brain region

midbrain: 14 nTPM
medulla oblongata: 14 nTPM
spinal cord: 13 nTPM
hypothalamus: 10 nTPM
thalamus: 9.8 nTPM
pons: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 24
Spermatogenesis-associated protein 24

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA24 as an antibody target. Whether an autoantibody or antibody against SPATA24 could matter depends on whether native SPATA24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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