CBX7
Chromobox protein homolog 7
Also known as: CBX7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95931
- Gene
- CBX7
- Ensembl
- ENSG00000100307
- Chromosome
- 22
- Canonical length
- 251 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
Canonical amino-acid sequenceUniProt
251 residues, UniProt reviewed canonical sequence.
>O95931|CBX7
1 MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK
61 EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA
121 GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP
181 DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA
241 EGFFRDRSGK FLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CBX7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 103 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 103 nTPM
- cerebral cortex: 94 nTPM
- blood vessel: 93 nTPM
- colon: 80 nTPM
- basal ganglia: 75 nTPM
- urinary bladder: 72 nTPM
Single-cell type
- adrenal medulla cells: 85 nCPM
- retinal horizontal cells: 58 nCPM
- vascular smooth muscle cells: 51 nCPM
- podocytes: 48 nCPM
- retinal bipolar cells: 47 nCPM
- smooth muscle cells: 42 nCPM
Immune cell
- neutrophil: 3.1 nTPM
- eosinophil: 2.9 nTPM
- naive CD4 T-cell: 2.6 nTPM
- naive CD8 T-cell: 2.5 nTPM
- T-reg: 2.2 nTPM
- memory CD4 T-cell: 2.1 nTPM
Brain region
- cerebral cortex: 140 nTPM
- amygdala: 103 nTPM
- cerebellum: 103 nTPM
- basal ganglia: 101 nTPM
- white matter: 100 nTPM
- medulla oblongata: 95 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.69
- gnomAD missense Z
- 1.3
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CBX7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CBX7 as an antibody target. Whether an autoantibody or antibody against CBX7 could matter depends on whether native CBX7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CBX7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CBX7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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