Seroatlas · Human Serome Atlas

UBE2D1

Ubiquitin-conjugating enzyme E2 D1

Also known as: E2(17)KB1, SFT, UB2D1_HUMAN, UBC4/5, UBCH5, UbcH5A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51668
Gene
UBE2D1
Ensembl
ENSG00000072401
Chromosome
10
Canonical length
147 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P51668|UBE2D1
     1  MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY
    61  PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV
   121  PDIAQIYKSD KEKYNRHARE WTQKYAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 130 nTPM
  • tongue: 61 nTPM
  • heart muscle: 31 nTPM
  • bone marrow: 31 nTPM
  • appendix: 16 nTPM
  • urinary bladder: 14 nTPM

Single-cell type

  • neutrophils: 1,082 nCPM
  • esophageal apical cells: 311 nCPM
  • myonuclei: 310 nCPM
  • monocytes: 275 nCPM
  • neutrophil progenitors: 250 nCPM
  • syncytiotrophoblasts: 211 nCPM

Immune cell

  • neutrophil: 113 nTPM
  • classical monocyte: 39 nTPM
  • intermediate monocyte: 27 nTPM
  • non-classical monocyte: 24 nTPM
  • total PBMC: 23 nTPM
  • myeloid DC: 20 nTPM

Brain region

  • pons: 11 nTPM
  • cerebellum: 10 nTPM
  • medulla oblongata: 10 nTPM
  • white matter: 10 nTPM
  • midbrain: 10 nTPM
  • spinal cord: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.12
gnomAD missense Z
2.03
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2D1 as an antibody target. Whether an autoantibody or antibody against UBE2D1 could matter depends on whether native UBE2D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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