Seroatlas · Human Serome Atlas

PCGF1

Polycomb group RING finger protein 1

Also known as: MGC10882, NSPC1, PCGF1_HUMAN, RNF68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSM1
Gene: PCGF1
Ensembl: ENSG00000115289
Chromosome: 2
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q9BSM1|PCGF1
     1  MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI
    61  TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE
   121  KRIREFYQSR GLDRVTQPTG EEPALSNLGL PFSSFDHSKA HYYRYDEQLN LCLERLSSGK
   181  DKNKSVLQNK YVRCSVRAEV RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR
   241  WFGKPSPLLL QYSVKEKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCGF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

ovary: 17 nTPM
bone marrow: 17 nTPM
retina: 17 nTPM
parathyroid gland: 17 nTPM
tongue: 16 nTPM
breast: 14 nTPM

Single-cell type

oocytes: 51 nCPM
late primary spermatocytes: 36 nCPM
decidual stromal cells: 31 nCPM
extravillous trophoblasts: 26 nCPM
syncytiotrophoblasts: 25 nCPM
esophageal basal cells: 19 nCPM

Immune cell

myeloid DC: 27 nTPM
T-reg: 24 nTPM
classical monocyte: 24 nTPM
non-classical monocyte: 23 nTPM
memory CD4 T-cell: 21 nTPM
intermediate monocyte: 20 nTPM

Brain region

white matter: 11 nTPM
cerebellum: 11 nTPM
pons: 11 nTPM
cerebral cortex: 10 nTPM
thalamus: 10 nTPM
basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.11
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCGF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCGF1 as an antibody target. Whether an autoantibody or antibody against PCGF1 could matter depends on whether native PCGF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCGF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCGF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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