Seroatlas · Human Serome Atlas

TNFAIP8L2

Tumor necrosis factor alpha-induced protein 8-like protein 2

Also known as: FLJ23467, TP8L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P589
Gene: TNFAIP8L2
Ensembl: ENSG00000163154
Chromosome: 1
Canonical length: 184 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be located in lysosome and nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q6P589|TNFAIP8L2
     1  MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRPQAQRVI
    61  KDLIKVAIKV AVLHRNGSFG PSELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL
   121  TECRDVLLEL VEHHLTPKSH GRIRHVFDHF SDPGLLTALY GPDFTQHLGK ICDGLRKLLD
   181  EGKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP8L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spleen: 38 nTPM
lymph node: 30 nTPM
appendix: 19 nTPM
thymus: 18 nTPM
tonsil: 17 nTPM
lung: 10 nTPM

Single-cell type

cdc: 0.8 nCPM
microglia: 0.8 nCPM
neutrophils: 0.5 nCPM
macrophages: 0.3 nCPM
monocytes: 0.3 nCPM
neutrophil progenitors: 0.3 nCPM

Immune cell

basophil: 318 nTPM
neutrophil: 294 nTPM
myeloid DC: 266 nTPM
total PBMC: 250 nTPM
eosinophil: 247 nTPM
classical monocyte: 239 nTPM

Brain region

white matter: 12 nTPM
medulla oblongata: 9.7 nTPM
spinal cord: 8.8 nTPM
thalamus: 8.6 nTPM
pons: 8.5 nTPM
cerebral cortex: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0.04
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFAIP8L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP8L2 as an antibody target. Whether an autoantibody or antibody against TNFAIP8L2 could matter depends on whether native TNFAIP8L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP8L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNFAIP8L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...