Seroatlas · Human Serome Atlas

RAP1GDS1

Rap1 GTPase-GDP dissociation stimulator 1

Also known as: GDS1_HUMAN, SmgGDS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52306
Gene
RAP1GDS1
Ensembl
ENSG00000138698
Chromosome
4
Canonical length
607 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>P52306|RAP1GDS1
     1  MDNLSDTLKK LKITAVDKTE DSLEGCLDCL LQALAQNNTE TSEKIQASGI LQLFASLLTP
    61  QSSCKAKVAN IIAEVAKNEF MRIPCVDAGL ISPLVQLLNS KDQEVLLQTG RALGNICYDS
   121  HEGRSAVDQA GGAQIVIDHL RSLCSITDPA NEKLLTVFCG MLMNYSNEND SLQAQLINMG
   181  VIPTLVKLLG IHCQNAALTE MCLVAFGNLA ELESSKEQFA STNIAEELVK LFKKQIEHDK
   241  REMIFEVLAP LAENDAIKLQ LVEAGLVECL LEIVQQKVDS DKEDDITELK TGSDLMVLLL
   301  LGDESMQKLF EGGKGSVFQR VLSWIPSNNH QLQLAGALAI ANFARNDANC IHMVDNGIVE
   361  KLMDLLDRHV EDGNVTVQHA ALSALRNLAI PVINKAKMLS AGVTEAVLKF LKSEMPPVQF
   421  KLLGTLRMLI DAQAEAAEQL GKNVKLVERL VEWCEAKDHA GVMGESNRLL SALIRHSKSK
   481  DVIKTIVQSG GIKHLVTMAT SEHVIMQNEA LVALALIAAL ELGTAEKDLE SAKLVQILHR
   541  LLADERSAPE IKYNSMVLIC ALMGSECLHK EVQDLAFLDV VSKLRSHENK SVAQQASLTE
   601  QRLTVES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP1GDS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 61 nTPM
  • retina: 61 nTPM
  • midbrain: 55 nTPM
  • cerebral cortex: 53 nTPM
  • hippocampal formation: 43 nTPM
  • basal ganglia: 42 nTPM

Single-cell type

  • rod photoreceptor cells: 504 nCPM
  • cone photoreceptor cells: 480 nCPM
  • early spermatids: 438 nCPM
  • oligodendrocytes: 408 nCPM
  • late spermatids: 376 nCPM
  • thymocytes: 348 nCPM

Immune cell

  • plasmacytoid DC: 61 nTPM
  • T-reg: 41 nTPM
  • NK-cell: 37 nTPM
  • basophil: 33 nTPM
  • non-classical monocyte: 29 nTPM
  • myeloid DC: 28 nTPM

Brain region

  • white matter: 119 nTPM
  • pons: 113 nTPM
  • thalamus: 106 nTPM
  • midbrain: 105 nTPM
  • medulla oblongata: 98 nTPM
  • cerebellum: 90 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAP1GDS1.

Disease | AllUniProt

Conditions RAP1GDS1 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Alfadhel syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.93
gnomAD missense Z
1.07
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAP1GDS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP1GDS1 as an antibody target. Whether an autoantibody or antibody against RAP1GDS1 could matter depends on whether native RAP1GDS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP1GDS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAP1GDS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAP1GDS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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