Seroatlas · Human Serome Atlas

GARRE1

Granule associated Rac and RHOG effector protein 1

Also known as: GRRE1_HUMAN, KIAA0355

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15063
Gene: GARRE1
Ensembl: ENSG00000166398
Chromosome: 19
Canonical length: 1070 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables CCR4-NOT complex binding activity and small GTPase binding activity. Involved in Rac protein signal transduction. Located in P-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1070 residues, UniProt reviewed canonical sequence.

>O15063|GARRE1
     1  MYCCSAQDSK MDYKRRFLLG GSKQKVQQHQ QYPMPELGRA LSAPLASTAT TAPLGSLTAA
    61  GSCHHAMPHT TPIADIQQGI SKYLDALNVF CRASTFLTDL FSTVFRNSHY SKAATQLKDV
   121  QEHVMEAASR LTSAIKPEIA KMLMELSAGA ANFTDQKEFS LQDIEVLGRC FLTVVQVHFQ
   181  FLTHALQKVQ PVAHSCFAEV IVPEKKNSGS GGGLSGMGHT PEVEEAVRSW RGAAEATSRL
   241  RERGCDGCLA GIEVQQLFCS QSAAIPEHQL KELNIKIDSA LQAYKIALES LGHCEYAMKA
   301  GFHLNPKAIE ASLQGCCSEA EAQQTGRRQT PPQPMQCELP TVPVQIGSHF LKGVSFNESA
   361  ADNLKLKTHT MLQLMKEAGC YNGITSRDDF PVTEVLNQVC PSTWRGACKT AVQLLFGQAG
   421  LVVVDTAQIE NKEAYAPQIS LEGSRIVVQV PSTWCLKEDP ATMSLLQRSL DPEKTLGLVD
   481  VLYTAVLDLN RWRAGREQAL PCIQIQLQRE ICDFGNQADL PSGNGNKSSG GLQKTFSKLT
   541  SRFTKKASCT SSSSSTNYSI QNTPSKNIFI AGCSEEKAKM PGNIDTRLQS ILNIGNFPRT
   601  TDPSQSAQNS SNTVANGFLM ERRENFLHGD DGKDEKGMNL PTDQEMQEVI DFLSGFNMGQ
   661  SHQGSPLVTR HNSAATAMVT EQKAGAMQPQ QPSLPVPPPP RAPQAGAHTP LTPQPGLAPQ
   721  QQSPKQQQPQ VQYYQHLLQP IGPQQPPPQP RAPGKWVHGS SQQPAQAVGA GLSPLGQWPG
   781  ISDLSSDLYS LGLVSSYMDN VMSEVLGQKP QGPRNNTWPN RDQSDGVFGM LGEILPFDPA
   841  VGSDPEFARY VAGVSQAMQQ KRQAQHGRRP GNPRGNWPPM DDAHRTWPFP EFFTEGDGLH
   901  GGWSGAQGDS ASSSDETSSA NGDSLFSMFS GPDLVAAVKQ RRKHSSGEQD TSTLPSPPLL
   961  TTVEDVNQDN KTKTWPPKAP WQHPSPLPST LPSPSAPLYA VTSPGSQWND TMQMLQSPVW
  1021  AATNDCSAAA FSYVQTPPQP PPPPAHKAAP KGFKAFPGKG ERRPAYLPQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARRE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

placenta: 22 nTPM
adipose tissue: 18 nTPM
breast: 16 nTPM
tongue: 16 nTPM
spleen: 15 nTPM
skeletal muscle: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 186 nCPM
vascular endothelial cells: 130 nCPM
distal convoluted tubule cells: 107 nCPM
renal collecting duct intercalated cells: 106 nCPM
microglia: 101 nCPM
loop of henle epithelial cells: 99 nCPM

Immune cell

T-reg: 3 nTPM
naive B-cell: 2.8 nTPM
memory B-cell: 2.3 nTPM
neutrophil: 2.2 nTPM
non-classical monocyte: 2.1 nTPM
memory CD4 T-cell: 1.8 nTPM

Brain region

white matter: 28 nTPM
cerebellum: 23 nTPM
medulla oblongata: 23 nTPM
thalamus: 23 nTPM
midbrain: 22 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Rac protein signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4745
Granule associated Rac and RHOG effector protein 1
Domain of unknown function (DUF4745)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GARRE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARRE1 as an antibody target. Whether an autoantibody or antibody against GARRE1 could matter depends on whether native GARRE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARRE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARRE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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