Seroatlas · Human Serome Atlas

PIP5K1A

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Also known as: PI51A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99755
Gene
PIP5K1A
Ensembl
ENSG00000143398
Chromosome
1
Canonical length
562 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nucleus; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q99755|PIP5K1A
     1  MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP
    61  IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF
   121  FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG
   181  SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR
   241  IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
   301  YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY
   361  STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK
   421  ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC
   481  ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET
   541  LQMLTTSTTL EKLEVAESEF TH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP5K1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • retina: 28 nTPM
  • skeletal muscle: 27 nTPM
  • placenta: 24 nTPM
  • tongue: 24 nTPM
  • thymus: 23 nTPM

Single-cell type

  • endometrial ciliated cells: 321 nCPM
  • ocular epithelial cells: 312 nCPM
  • myonuclei: 309 nCPM
  • endometrial glandular cells: 263 nCPM
  • cone photoreceptor cells: 244 nCPM
  • podocytes: 228 nCPM

Immune cell

  • neutrophil: 8.9 nTPM
  • plasmacytoid DC: 6.7 nTPM
  • memory B-cell: 6.6 nTPM
  • myeloid DC: 6.4 nTPM
  • eosinophil: 5.7 nTPM
  • intermediate monocyte: 4.7 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • white matter: 34 nTPM
  • cerebellum: 34 nTPM
  • hypothalamus: 34 nTPM
  • cerebral cortex: 33 nTPM
  • basal ganglia: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIP5K1A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 40 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0
gnomAD missense Z
2.58
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIP5K1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIP5K1A as an antibody target. Whether an autoantibody or antibody against PIP5K1A could matter depends on whether native PIP5K1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIP5K1A is annotated at the cell surface, where native PIP5K1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIP5K1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIP5K1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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