Seroatlas · Human Serome Atlas

TBC1D2

TBC1 domain family member 2A

Also known as: Armus, PARIS1, TBC1D2A, TBD2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYX2
Gene: TBC1D2
Ensembl: ENSG00000095383
Chromosome: 9
Canonical length: 928 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables GTPase activator activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

928 residues, UniProt reviewed canonical sequence.

>Q9BYX2|TBC1D2
     1  MEGAGENAPE SSSSAPGSEE SARDPQVPPP EEESGDCARS LEAVPKKLCG YLSKFGGKGP
    61  IRGWKSRWFF YDERKCQLYY SRTAQDANPL DSIDLSSAVF DCKADAEEGI FEIKTPSRVI
   121  TLKAATKQAM LYWLQQLQMK RWEFHNSPPA PPATPDAALA GNGPVLHLEL GQEEAELEEF
   181  LCPVKTPPGL VGVAAALQPF PALQNISLKH LGTEIQNTMH NIRGNKQAQG TGHEPPGEDS
   241  PQSGEPQREE QPLASDASTP GREPEDSPKP APKPSLTISF AQKAKRQNNT FPFFSEGITR
   301  NRTAQEKVAA LEQQVLMLTK ELKSQKELVK ILHKALEAAQ QEKRASSAYL AAAEDKDRLE
   361  LVRHKVRQIA ELGRRVEALE QERESLAHTA SLREQQVQEL QQHVQLLMDK NHAKQQVICK
   421  LSEKVTQDFT HPPDQSPLRP DAANRDFLSQ QGKIEHLKDD MEAYRTQNCF LNSEIHQVTK
   481  IWRKVAEKEK ALLTKCAYLQ ARNCQVESKY LAGLRRLQEA LGDEASECSE LLRQLVQEAL
   541  QWEAGEASSD SIELSPISKY DEYGFLTVPD YEVEDLKLLA KIQALESRSH HLLGLEAVDR
   601  PLRERWAALG DLVPSAELKQ LLRAGVPREH RPRVWRWLVH LRVQHLHTPG CYQELLSRGQ
   661  AREHPAARQI ELDLNRTFPN NKHFTCPTSS FPDKLRRVLL AFSWQNPTIG YCQGLNRLAA
   721  IALLVLEEEE SAFWCLVAIV ETIMPADYYC NTLTASQVDQ RVLQDLLSEK LPRLMAHLGQ
   781  HHVDLSLVTF NWFLVVFADS LISNILLRVW DAFLYEGTKV VFRYALAIFK YNEKEILRLQ
   841  NGLEIYQYLR FFTKTISNSR KLMNIAFNDM NPFRMKQLRQ LRMVHRERLE AELRELEQLK
   901  AEYLERRASR RRAVSEGCAS EDEVEGEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

esophagus: 36 nTPM
lung: 31 nTPM
skin: 23 nTPM
spinal cord: 20 nTPM
liver: 19 nTPM
vagina: 17 nTPM

Single-cell type

alveolar cells type 1: 341 nCPM
monocytes: 136 nCPM
respiratory basal cells: 123 nCPM
neutrophils: 117 nCPM
prostatic hillock cells: 113 nCPM
papillary tip epithelial cells: 113 nCPM

Immune cell

classical monocyte: 28 nTPM
intermediate monocyte: 15 nTPM
non-classical monocyte: 12 nTPM
neutrophil: 12 nTPM
total PBMC: 11 nTPM
myeloid DC: 10 nTPM

Brain region

cerebral cortex: 48 nTPM
thalamus: 42 nTPM
white matter: 41 nTPM
pons: 26 nTPM
basal ganglia: 24 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of GTPase activity

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D2 as an antibody target. Whether an autoantibody or antibody against TBC1D2 could matter depends on whether native TBC1D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D2 is annotated at the cell surface, where native TBC1D2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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