Seroatlas · Human Serome Atlas

NOXA1

NADPH oxidase activator 1

Also known as: FLJ25475, NOXA1_HUMAN, NY-CO-31, SDCCAG31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UR1
Gene: NOXA1
Ensembl: ENSG00000188747
Chromosome: 9
Canonical length: 476 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q86UR1|NOXA1
     1  MASLGDLVRA WHLGAQAVDR GDWARALHLF SGVPAPPARL CFNAGCVHLL AGDPEAALRA
    61  FDQAVTKDTC MAVGFFQRGV ANFQLARFQE ALSDFWLALE QLRGHAAIDY TQLGLRFKLQ
   121  AWEVLHNVAS AQCQLGLWTE AASSLREAMS KWPEGSLNGL DSALDQVQRR GSLPPRQVPR
   181  GEVFRPHRWH LKHLEPVDFL GKAKVVASAI PDDQGWGVRP QQPQGPGANH DARSLIMDSP
   241  RAGTHQGPLD AETEVGADRC TSTAYQEQRP QVEQVGKQAP LSPGLPAMGG PGPGPCEDPA
   301  GAGGAGAGGS EPLVTVTVQC AFTVALRARR GADLSSLRAL LGQALPHQAQ LGQLSYLAPG
   361  EDGHWVPIPE EESLQRAWQD AAACPRGLQL QCRGAGGRPV LYQVVAQHSY SAQGPEDLGF
   421  RQGDTVDVLC EVDQAWLEGH CDGRIGIFPK CFVVPAGPRM SGAPGRLPRS QQGDQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOXA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

duodenum: 22 nTPM
salivary gland: 22 nTPM
skin: 22 nTPM
stomach: 21 nTPM
pancreas: 17 nTPM
small intestine: 16 nTPM

Single-cell type

foveolar cells: 69 nCPM
colonocytes: 62 nCPM
enterocytes: 60 nCPM
ependymal cells: 48 nCPM
tuft cells: 46 nCPM
brain inhibitory neurons: 42 nCPM

Immune cell

non-classical monocyte: 2.6 nTPM
intermediate monocyte: 0.8 nTPM
myeloid DC: 0.8 nTPM
NK-cell: 0.7 nTPM
classical monocyte: 0.5 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

cerebral cortex: 45 nTPM
medulla oblongata: 34 nTPM
thalamus: 32 nTPM
midbrain: 32 nTPM
basal ganglia: 32 nTPM
amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOXA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOXA1 as an antibody target. Whether an autoantibody or antibody against NOXA1 could matter depends on whether native NOXA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOXA1 is annotated at the cell surface, where native NOXA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NOXA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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