Seroatlas · Human Serome Atlas

S100A8

Protein S100-A8

Also known as: 60B8AG, CAGA, CFAG, CGLA, MRP-8, MRP8, P8, S100-A8, S10A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05109
Gene
S100A8
Ensembl
ENSG00000143546
Chromosome
1
Canonical length
93 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Intermediate filaments,Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>P05109|S100A8
     1  MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI
    61  NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
36,526 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 36,526 nTPM
  • bone marrow: 33,387 nTPM
  • vagina: 16,753 nTPM
  • cervix: 14,478 nTPM
  • tonsil: 8,361 nTPM
  • salivary gland: 5,489 nTPM

Single-cell type

  • esophageal apical cells: 442,327 nCPM
  • esophageal suprabasal cells: 118,515 nCPM
  • neutrophils: 52,050 nCPM
  • neutrophil progenitors: 51,793 nCPM
  • suprabasal keratinocytes: 23,823 nCPM
  • monocyte progenitors: 14,611 nCPM

Immune cell

  • neutrophil: 53,446 nTPM
  • classical monocyte: 26,967 nTPM
  • total PBMC: 25,067 nTPM
  • myeloid DC: 4,704 nTPM
  • eosinophil: 3,037 nTPM
  • intermediate monocyte: 2,008 nTPM

Brain region

  • cerebral cortex: 66 nTPM
  • pons: 23 nTPM
  • medulla oblongata: 17 nTPM
  • basal ganglia: 14 nTPM
  • thalamus: 14 nTPM
  • white matter: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about S100A8.

Disease | ImmuneIEDB

Conditions an epitope on S100A8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0.14
gnomAD missense Z
0.04
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100A8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100A8 as an antibody target. Whether an autoantibody or antibody against S100A8 could matter depends on whether native S100A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100A8 is annotated at the cell surface, where native S100A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S100A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S100A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...