Seroatlas · Human Serome Atlas

UNKL

Putative E3 ubiquitin-protein ligase UNKL

Also known as: C16orf28, FLJ23360, UNKL_HUMAN, ZC3H5L, ZC3HDC5L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9P5
Gene
UNKL
Ensembl
ENSG00000059145
Chromosome
16
Canonical length
680 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>Q9H9P5|UNKL
     1  MPSVSKAAAA ALSGSPPQTE KPTHYRYLKE FRTEQCPLFS QHKCAQHRPF TCFHWHFLNQ
    61  RRRRPLRRRD GTFNYSPDVY CSKYNEATGV CPDGDECPYL HRTTGDTERK YHLRYYKTGT
   121  CIHETDARGH CVKNGLHCAF AHGPLDLRPP VCDVRELQAQ EALQNGQLGG GEGVPDLQPG
   181  VLASQAMIEK ILSEDPRWQD ANFVLGSYKT EQCPKPPRLC RQGYACPHYH NSRDRRRNPR
   241  RFQYRSTPCP SVKHGDEWGE PSRCDGGDGC QYCHSRTEQQ FHPESTKCND MRQTGYCPRG
   301  PFCAFAHVEK SLGMVNEWGC HDLHLTSPSS TGSGQPGNAK RRDSPAEGGP RGSEQDSKQN
   361  HLAVFAAVHP PAPSVSSSVA SSLASSAGSG SSSPTALPAP PARALPLGPA SSTVEAVLGS
   421  ALDLHLSNVN IASLEKDLEE QDGHDLGAAG PRSLAGSAPV AIPGSLPRAP SLHSPSSAST
   481  SPLGSLSQPL PGPVGSSAMT PPQQPPPLRS EPGTLGSAAS SYSPLGLNGV PGSIWDFVSG
   541  SFSPSPSPIL SAGPPSSSSA SPNGAELARV RRQLDEAKRK IRQWEESWQQ VKQVCDAWQR
   601  EAQEAKERAR VADSDRQLAL QKKEEVEAQV IFQLRAKQCV ACRERAHGAV LRPCQHHILC
   661  EPCAATAPEC PYCKGQPLQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNKL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 14 nTPM
  • ovary: 11 nTPM
  • skeletal muscle: 10 nTPM
  • endometrium: 8.9 nTPM
  • fallopian tube: 8.1 nTPM
  • spleen: 8.1 nTPM

Single-cell type

  • oocytes: 74 nCPM
  • neutrophils: 68 nCPM
  • adrenal cortex cells: 56 nCPM
  • tuft cells: 46 nCPM
  • rod photoreceptor cells: 42 nCPM
  • adipocytes: 41 nCPM

Immune cell

  • neutrophil: 3.3 nTPM
  • basophil: 2.7 nTPM
  • eosinophil: 2.6 nTPM
  • gdT-cell: 2 nTPM
  • plasmacytoid DC: 1.8 nTPM
  • naive CD4 T-cell: 1.4 nTPM

Brain region

  • pons: 40 nTPM
  • cerebellum: 40 nTPM
  • medulla oblongata: 39 nTPM
  • cerebral cortex: 37 nTPM
  • thalamus: 35 nTPM
  • midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.82
gnomAD missense Z
0.82
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UNKL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNKL as an antibody target. Whether an autoantibody or antibody against UNKL could matter depends on whether native UNKL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNKL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNKL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UNKL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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