PLXNB3

Protein identityUniProt · HPA

UniProt accession

Q9ULL4

Gene

PLXNB3

Ensembl

ENSG00000198753

Chromosome

X

Canonical length

1909 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

1909 residues, UniProt reviewed canonical sequence.

>Q9ULL4|PLXNB3
     1  MCHAAQETPL LHHFMAPVMA RWPPFGLCLL LLLLSPPPLP LTGAHRFSAP NTTLNHLALA
    61  PGRGTLYVGA VNRLFQLSPE LQLEAVAVTG PVIDSPDCVP FRDPAECPQA QLTDNANQLL
   121  LVSSRAQELV ACGQVRQGVC ETRRLGDVAE VLYQAEDPGD GQFVAANTPG VATVGLVVPL
   181  PGRDLLLVAR GLAGKLSAGV PPLAIRQLAG SQPFSSEGLG RLVVGDFSDY NNSYVGAFAD
   241  ARSAYFVFRR RGARAQAEYR SYVARVCLGD TNLYSYVEVP LACQGQGLIQ AAFLAPGTLL
   301  GVFAAGPRGT QAALCAFPMV ELGASMEQAR RLCYTAGGRG PSGAEEATVE YGVTSRCVTL
   361  PLDSPESYPC GDEHTPSPIA GRQPLEVQPL LKLGQPVSAV AALQADGHMI AFLGDTQGQL
   421  YKVFLHGSQG QVYHSQQVGP PGSAISPDLL LDSSGSHLYV LTAHQVDRIP VAACPQFPDC
   481  ASCLQAQDPL CGWCVLQGRC TRKGQCGRAG QLNQWLWSYE EDSHCLHIQS LLPGHHPRQE
   541  QGQVTLSVPR LPILDADEYF HCAFGDYDSL AHVEGPHVAC VTPPQDQVPL NPPGTDHVTV
   601  PLALMFEDVT VAATNFSFYD CSAVQALEAA APCRACVGSI WRCHWCPQSS HCVYGEHCPE
   661  GERTIYSAQE VDIQVRGPGA CPQVEGLAGP HLVPVGWESH LALRVRNLQH FRGLPASFHC
   721  WLELPGELRG LPATLEETAG DSGLIHCQAH QFYPSMSQRE LPVPIYVTQG EAQRLDNTHA
   781  LYVILYDCAM GHPDCSHCQA ANRSLGCLWC ADGQPACRYG PLCPPGAVEL LCPAPSIDAV
   841  EPLTGPPEGG LALTILGSNL GRAFADVQYA VSVASRPCNP EPSLYRTSAR IVCVTSPAPN
   901  GTTGPVRVAI KSQPPGISSQ HFTYQDPVLL SLSPRWGPQA GGTQLTIRGQ HLQTGGNTSA
   961  FVGGQPCPIL EPVCPEAIVC RTRPQAAPGE AAVLVVFGHA QRTLLASPFR YTANPQLVAA
  1021  EPSASFRGGG RLIRVRGTGL DVVQRPLLSV WLEADAEVQA SRAQPQDPQP RRSCGAPAAD
  1081  PQACIQLGGG LLQCSTVCSV NSSSLLLCRS PAVPDRAHPQ RVFFTLDNVQ VDFASASGGQ
  1141  GFLYQPNPRL APLSREGPAR PYRLKPGHVL DVEGEGLNLG ISKEEVRVHI GRGECLVKTL
  1201  TRTHLYCEPP AHAPQPANGS GLPQFVVQMG NVQLALGPVQ YEAEPPLSAF PVEAQAGVGM
  1261  GAAVLIAAVL LLTLMYRHKS KQALRDYQKV LVQLESLETG VGDQCRKEFT DLMTEMTDLS
  1321  SDLEGSGIPF LDYRTYAERA FFPGHGGCPL QPKPEGPGED GHCATVRQGL TQLSNLLNSK
  1381  LFLLTLIHTL EEQPSFSQRD RCHVASLLSL ALHGKLEYLT DIMRTLLGDL AAHYVHRNPK
  1441  LMLRRTETMV EKLLTNWLSI CLYAFLREVA GEPLYMLFRA IQYQVDKGPV DAVTGKAKRT
  1501  LNDSRLLRED VEFQPLTLMV LVGPGAGGAA GSSEMQRVPA RVLDTDTITQ VKEKVLDQVY
  1561  KGTPFSQRPS VHALDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVGL
  1621  VPQLHRGSTI SQSLAQRCPL GENIPTLEDG EEGGVCLWHL VKATEEPEGA KVRCSSLRER
  1681  EPARAKAIPE IYLTRLLSMK GTLQKFVDDT FQAILSVNRP IPIAVKYLFD LLDELAEKHG
  1741  IEDPGTLHIW KTNSLLLRFW VNALKNPQLI FDVRVSDNVD AILAVIAQTF IDSCTTSEHK
  1801  VGRDSPVNKL LYAREIPRYK QMVERYYADI RQSSPASYQE MNSALAELSG NYTSAPHCLE
  1861  ALQELYNHIH RYYDQIISAL EEDPVGQKLQ LACRLQQVAA LVENKVTDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLXNB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

85 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.23

gnomAD missense Z

0.23

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell chemotaxis
• homophilic cell adhesion via plasma membrane adhesion molecules
• negative regulation of cell adhesion
• negative regulation of cell migration
• negative regulation of GTPase activity
• negative regulation of lamellipodium assembly
• positive chemotaxis
• positive regulation of axonogenesis
• positive regulation of endothelial cell proliferation
• positive regulation of neuron projection development
• regulation of cell shape
• semaphorin-plexin signaling pathway
• synapse assembly

Molecular functions

• cell-cell adhesion mediator activity
• protein domain specific binding
• Rho GDP-dissociation inhibitor binding
• semaphorin receptor activity

Cellular components

• cell surface
• plasma membrane
• semaphorin receptor complex

Protein domainsUniProt · Pfam · InterPro

• Sema domain
• Plexin repeat
• IPT domain
• Rho GTPase activation protein
• Plexin, cytoplasmic RasGAP domain
• Immunoglobulin-like fold
• Immunoglobulin E-set
• WD40/YVTN repeat-like-containing domain superfamily
• PSI domain
• Plexin family
• Sema domain superfamily
• Plexin, TIG domain 1
• Plexin, TIG domain 2
• Plexin, cytoplasmic RhoGTPase-binding domain
• Plexin-B, PSI domain
• Sema domain
• Plexin repeat
• IPT/TIG domain
• Plexin cytoplasmic RasGAP domain
• TIG domain
• TIG domain found in plexin
• Plexin cytoplasmic RhoGTPase-binding domain
• Plexin-B, PSI domain
• Plexin A/B, PSI domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Neurogenesis
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PLXNB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARHGDIA
• RIT2
• FSCN1
• SEMA4A
• RAC1