Seroatlas · Human Serome Atlas

PAK2

Serine/threonine-protein kinase PAK 2

Also known as: PAK2_HUMAN, PAK65, PAKgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13177
Gene
PAK2
Ensembl
ENSG00000180370
Chromosome
3
Canonical length
524 aa
Protein class
Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Focal adhesion sites,Cytosol

OverviewNCBI Gene

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q13177|PAK2
     1  MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT
    61  EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP
   121  QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP
   181  PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV
   241  SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE
   301  LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH
   361  ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY
   421  GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC
   481  LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 42 nTPM
  • spleen: 41 nTPM
  • lymph node: 38 nTPM
  • tonsil: 37 nTPM
  • appendix: 33 nTPM
  • urinary bladder: 32 nTPM

Single-cell type

  • neutrophils: 826 nCPM
  • neutrophil progenitors: 418 nCPM
  • monocytes: 351 nCPM
  • monocyte progenitors: 304 nCPM
  • innate lymphoid cells: 269 nCPM
  • kupffer cells: 254 nCPM

Immune cell

  • eosinophil: 48 nTPM
  • neutrophil: 48 nTPM
  • basophil: 38 nTPM
  • myeloid DC: 26 nTPM
  • intermediate monocyte: 23 nTPM
  • non-classical monocyte: 21 nTPM

Brain region

  • white matter: 64 nTPM
  • medulla oblongata: 53 nTPM
  • cerebellum: 47 nTPM
  • hypothalamus: 47 nTPM
  • spinal cord: 47 nTPM
  • basal ganglia: 46 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PAK2.

Disease | AllUniProt

Conditions PAK2 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
3.4
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAK2 as an antibody target. Whether an autoantibody or antibody against PAK2 could matter depends on whether native PAK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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