Seroatlas · Human Serome Atlas

PRKAB2

5'-AMP-activated protein kinase subunit beta-2

Also known as: AAKB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43741
Gene
PRKAB2
Ensembl
ENSG00000131791
Chromosome
1
Canonical length
272 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>O43741|PRKAB2
     1  MGNTTSDRVS GERHGAKAAR SEGAGGHAPG KEHKIMVGST DDPSVFSLPD SKLPGDKEFV
    61  SWQQDLEDSV KPTQQARPTV IRWSEGGKEV FISGSFNNWS TKIPLIKSHN DFVAILDLPE
   121  GEHQYKFFVD GQWVHDPSEP VVTSQLGTIN NLIHVKKSDF EVFDALKLDS MESSETSCRD
   181  LSSSPPGPYG QEMYAFRSEE RFKSPPILPP HLLQVILNKD TNISCDPALL PEPNHVMLNH
   241  LYALSIKDSV MVLSATHRYK KKYVTTLLYK PI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKAB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 97 nTPM
  • skeletal muscle: 91 nTPM
  • parathyroid gland: 61 nTPM
  • liver: 53 nTPM
  • pancreas: 33 nTPM
  • duodenum: 30 nTPM

Single-cell type

  • platelets: 102 nCPM
  • extravillous trophoblasts: 71 nCPM
  • hepatocytes: 68 nCPM
  • enterocytes: 66 nCPM
  • gastric chief cells: 66 nCPM
  • parietal cells: 53 nCPM

Immune cell

  • NK-cell: 1.6 nTPM
  • basophil: 0.9 nTPM
  • MAIT T-cell: 0.7 nTPM
  • eosinophil: 0.6 nTPM
  • myeloid DC: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM

Brain region

  • cerebellum: 19 nTPM
  • cerebral cortex: 18 nTPM
  • white matter: 16 nTPM
  • spinal cord: 16 nTPM
  • pons: 16 nTPM
  • thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.73
gnomAD missense Z
1.5
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKAB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKAB2 as an antibody target. Whether an autoantibody or antibody against PRKAB2 could matter depends on whether native PRKAB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKAB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKAB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKAB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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