Seroatlas · Human Serome Atlas

PRMT6

Protein arginine N-methyltransferase 6

Also known as: ANM6_HUMAN, FLJ10559, HRMT1L6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LA8
Gene
PRMT6
Ensembl
ENSG00000198890
Chromosome
1
Canonical length
375 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q96LA8|PRMT6
     1  MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM
    61  IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA
   121  REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE
   181  GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG
   241  LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE
   301  SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK
   361  VGDQEEKTKD FAMED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRMT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 13 nTPM
  • kidney: 11 nTPM
  • pancreas: 10 nTPM
  • thymus: 9.6 nTPM
  • hypothalamus: 9.3 nTPM
  • adrenal gland: 9.2 nTPM

Single-cell type

  • cytotrophoblasts: 22 nCPM
  • migrating cytotrophoblasts: 19 nCPM
  • erythrocyte progenitors: 18 nCPM
  • neuroendocrine cells: 17 nCPM
  • extravillous trophoblasts: 17 nCPM
  • pancreatic islet cells: 14 nCPM

Immune cell

  • NK-cell: 18 nTPM
  • plasmacytoid DC: 17 nTPM
  • myeloid DC: 14 nTPM
  • non-classical monocyte: 12 nTPM
  • intermediate monocyte: 12 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • thalamus: 17 nTPM
  • hypothalamus: 14 nTPM
  • midbrain: 13 nTPM
  • medulla oblongata: 12 nTPM
  • white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRMT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRMT6 as an antibody target. Whether an autoantibody or antibody against PRMT6 could matter depends on whether native PRMT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRMT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRMT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRMT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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