Seroatlas · Human Serome Atlas

PAIP2

Polyadenylate-binding protein-interacting protein 2

Also known as: PAIP2_HUMAN, PAIP2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPZ3
Gene: PAIP2
Ensembl: ENSG00000120727
Chromosome: 5
Canonical length: 127 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q9BPZ3|PAIP2
     1  MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC
    61  FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP
   121  GVKYGNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 162 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 162 nTPM
skeletal muscle: 159 nTPM
testis: 158 nTPM
retina: 156 nTPM
tongue: 151 nTPM
spinal cord: 144 nTPM

Single-cell type

late spermatids: 4,608 nCPM
early spermatids: 935 nCPM
syncytiotrophoblasts: 673 nCPM
platelets: 669 nCPM
late primary spermatocytes: 631 nCPM
esophageal apical cells: 530 nCPM

Immune cell

neutrophil: 805 nTPM
eosinophil: 738 nTPM
total PBMC: 578 nTPM
basophil: 571 nTPM
T-reg: 451 nTPM
non-classical monocyte: 383 nTPM

Brain region

white matter: 156 nTPM
pons: 128 nTPM
choroid plexus: 122 nTPM
cerebellum: 119 nTPM
hypothalamus: 119 nTPM
medulla oblongata: 119 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.55
gnomAD missense Z: 1.4
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAIP2 as an antibody target. Whether an autoantibody or antibody against PAIP2 could matter depends on whether native PAIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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