Seroatlas · Human Serome Atlas

EIF4E

Eukaryotic translation initiation factor 4E

Also known as: EIF4E1, EIF4EL1, EIF4F, IF4E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P06730
Gene
EIF4E
Ensembl
ENSG00000151247
Chromosome
4
Canonical length
217 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P06730|EIF4E
     1  MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL
    61  RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ
   121  QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG
   181  RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • testis: 58 nTPM
  • tonsil: 54 nTPM
  • bone marrow: 54 nTPM
  • urinary bladder: 51 nTPM
  • retina: 50 nTPM
  • thymus: 50 nTPM

Single-cell type

  • late spermatids: 321 nCPM
  • esophageal apical cells: 207 nCPM
  • basal keratinocytes: 194 nCPM
  • monocytes: 190 nCPM
  • suprabasal keratinocytes: 188 nCPM
  • ocular epithelial cells: 155 nCPM

Immune cell

  • eosinophil: 59 nTPM
  • non-classical monocyte: 55 nTPM
  • NK-cell: 55 nTPM
  • memory B-cell: 50 nTPM
  • total PBMC: 50 nTPM
  • naive CD4 T-cell: 48 nTPM

Brain region

  • spinal cord: 73 nTPM
  • white matter: 67 nTPM
  • hypothalamus: 66 nTPM
  • cerebellum: 63 nTPM
  • midbrain: 61 nTPM
  • cerebral cortex: 59 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF4E.

Disease | AllUniProt

Conditions EIF4E is implicated in, by any mechanism.

Disease | ImmuneIEDB

Conditions an epitope on EIF4E was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.94
gnomAD missense Z
2.58
DepMap mean gene effect
-1.52
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4E as an antibody target. Whether an autoantibody or antibody against EIF4E could matter depends on whether native EIF4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF4E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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