Seroatlas · Human Serome Atlas

NCBP1

Nuclear cap-binding protein subunit 1

Also known as: CBP80, NCBP, NCBP1_HUMAN, Sto1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q09161
Gene
NCBP1
Ensembl
ENSG00000136937
Chromosome
9
Canonical length
790 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q09161|NCBP1
     1  MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL EGLAGVLEAD
    61  LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF GGEFVEAMIR QLKESLKANN
   121  YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE NFVSVTQEED VPQVRRDWYV YAFLSSLPWV
   181  GKELYEKKDA EMDRIFANTE SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK
   241  KDRWQERHIL RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG
   301  PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH IVEVIFAELF
   361  QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM RLDTMNTTCV DRFINWFSHH
   421  LSNFQFRWSW EDWSDCLSQD PESPKPKFVR EVLEKCMRLS YHQRILDIVP PTFSALCPAN
   481  PTCIYKYGDE SSNSLPGHSV ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN
   541  PLKIEVFVQT LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM
   601  IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK HVLKIQKELE
   661  EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE SAQSEQKNLF LVIFQRFIMI
   721  LTEHLVRCET DGTSVLTPWY KNCIERLQQI FLQHHQIIQQ YMVTLENLLF TAELDPHILA
   781  VFQQFCALQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • retina: 28 nTPM
  • bone marrow: 28 nTPM
  • thymus: 20 nTPM
  • lymph node: 18 nTPM
  • skeletal muscle: 18 nTPM
  • tonsil: 17 nTPM

Single-cell type

  • cardiomyocytes: 203 nCPM
  • epicardial cells: 177 nCPM
  • myonuclei: 103 nCPM
  • adipocytes: 66 nCPM
  • monocyte progenitors: 61 nCPM
  • neutrophil progenitors: 58 nCPM

Immune cell

  • basophil: 14 nTPM
  • non-classical monocyte: 14 nTPM
  • intermediate monocyte: 13 nTPM
  • myeloid DC: 13 nTPM
  • NK-cell: 13 nTPM
  • classical monocyte: 10 nTPM

Brain region

  • cerebellum: 74 nTPM
  • white matter: 49 nTPM
  • basal ganglia: 43 nTPM
  • cerebral cortex: 43 nTPM
  • hippocampal formation: 40 nTPM
  • medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
3.52
DepMap mean gene effect
-1.42
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCBP1 as an antibody target. Whether an autoantibody or antibody against NCBP1 could matter depends on whether native NCBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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