Seroatlas · Human Serome Atlas

PAN3

PAN2-PAN3 deadenylation complex subunit PAN3

Also known as: PAN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q58A45
Gene
PAN3
Ensembl
ENSG00000152520
Chromosome
13
Canonical length
887 aa
Protein class
Enzymes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

887 residues, UniProt reviewed canonical sequence.

>Q58A45|PAN3
     1  MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY
    61  GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG
   121  DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY
   181  PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK PRKYRLGMLE
   241  ERLVPMGSKA RKAKNPIGCL ADRCKSGVPI NMVWWNRVTE NNLQTPNPTA SEFIPKGGST
   301  SRLSNVSQSN MSAFSQVFSH PSMGSPATAG LAPGMSLSAG SSPLHSPKIT PHTSPAPRRR
   361  SHTPNPASYM VPSSASTSVN NPVSQTPSSG QVIQKETVGG TTYFYTDTTP APLTGMVFPN
   421  YHIYPPTAPH VAYMQPKANA PSFFMADELR QELINRHLIT MAQIDQADMP AVPTEVDSYH
   481  SLFPLEPLPP PNRIQKSSNF GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW
   541  KKIQHSNIVT LREVFTTKAF AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH
   601  EGPLPRQHAG LLPESLIWAY IVQLSSALRT IHTAGLACRV MDPTKILITG KTRLRVNCVG
   661  VFDVLTFDNS QNNNPLALMA QYQQADLISL GKVVLALACN SLAGIQRENL QKAMELVTIN
   721  YSSDLKNLIL YLLTDQNRMR SVNDIMPMIG ARFYTQLDAA QMRNDVIEED LAKEVQNGRL
   781  FRLLAKLGTI NERPEFQKDP TWSETGDRYL LKLFRDHLFH QVTEAGAPWI DLSHIISCLN
   841  KLDAGVPEKI SLISRDEKSV LVVTYSDLKR CFENTFQELI AAANGQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 30 nTPM
  • cerebellum: 26 nTPM
  • spleen: 24 nTPM
  • lymph node: 20 nTPM
  • thymus: 20 nTPM
  • epididymis: 20 nTPM

Single-cell type

  • neutrophils: 1,437 nCPM
  • podocytes: 816 nCPM
  • thymocytes: 798 nCPM
  • neutrophil progenitors: 774 nCPM
  • hematopoietic stem cells: 650 nCPM
  • sertoli cells: 644 nCPM

Immune cell

  • basophil: 23 nTPM
  • neutrophil: 23 nTPM
  • plasmacytoid DC: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • eosinophil: 13 nTPM
  • memory B-cell: 12 nTPM

Brain region

  • cerebellum: 30 nTPM
  • choroid plexus: 22 nTPM
  • white matter: 20 nTPM
  • medulla oblongata: 14 nTPM
  • basal ganglia: 14 nTPM
  • spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
2.52
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAN3 as an antibody target. Whether an autoantibody or antibody against PAN3 could matter depends on whether native PAN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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