Seroatlas · Human Serome Atlas

TOB1

Protein Tob1

Also known as: APRO5, TOB, TOB1_HUMAN, TROB, TROB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50616
Gene: TOB1
Ensembl: ENSG00000141232
Chromosome: 17
Canonical length: 345 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>P50616|TOB1
     1  MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHI
    61  GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDNNEN
   121  GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA
   181  TFAATKFGST KMKNSGRSNK VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP
   241  QQQQQPAQPP PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP
   301  LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 199 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 199 nTPM
pancreas: 196 nTPM
skeletal muscle: 167 nTPM
liver: 156 nTPM
blood vessel: 142 nTPM
skin: 126 nTPM

Single-cell type

prostatic club cells: 622 nCPM
prostatic hillock cells: 590 nCPM
esophageal apical cells: 517 nCPM
ocular epithelial cells: 478 nCPM
urothelial cells: 471 nCPM
basal prostatic cells: 459 nCPM

Immune cell

basophil: 419 nTPM
eosinophil: 286 nTPM
MAIT T-cell: 270 nTPM
gdT-cell: 246 nTPM
naive CD8 T-cell: 234 nTPM
memory CD4 T-cell: 223 nTPM

Brain region

choroid plexus: 110 nTPM
midbrain: 86 nTPM
hypothalamus: 68 nTPM
medulla oblongata: 66 nTPM
white matter: 66 nTPM
pons: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.95
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOB1 as an antibody target. Whether an autoantibody or antibody against TOB1 could matter depends on whether native TOB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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