Seroatlas · Human Serome Atlas

ENDOV

Endonuclease V

Also known as: ENDOV_HUMAN, FLJ35220

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8Q3
Gene: ENDOV
Ensembl: ENSG00000173818
Chromosome: 17
Canonical length: 282 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables DNA binding activity; RNA endonuclease activity, producing 5'-phosphomonoesters; and single-stranded RNA binding activity. Predicted to be involved in DNA repair. Located in cytoplasmic stress granule and nucleolus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q8N8Q3|ENDOV
     1  MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG VDVSFVKGDS
    61  VRACASLVVL SFPELEVVYE ESRMVSLTAP YVSGFLAFRE VPFLLELVQQ LREKEPGLMP
   121  QVLLVDGNGV LHHRGFGVAC HLGVLTDLPC VGVAKKLLQV DGLENNALHK EKIRLLQTRG
   181  DSFPLLGDSG TVLGMALRSH DRSTRPLYIS VGHRMSLEAA VRLTCCCCRF RIPEPVRQAD
   241  ICSREHIRKS LGLPGPPTPR SPKAQRPVAC PKGDSGESSA LC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENDOV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
testis: 23 nTPM
kidney: 15 nTPM
liver: 15 nTPM
skin: 14 nTPM
basal ganglia: 13 nTPM

Single-cell type

enterocytes: 59 nCPM
differentiating spermatogonia: 57 nCPM
granulosa cells: 56 nCPM
rod photoreceptor cells: 55 nCPM
undifferentiated spermatogonia: 50 nCPM
late primary spermatocytes: 44 nCPM

Immune cell

plasmacytoid DC: 27 nTPM
myeloid DC: 20 nTPM
naive B-cell: 19 nTPM
basophil: 15 nTPM
intermediate monocyte: 13 nTPM
classical monocyte: 13 nTPM

Brain region

cerebellum: 29 nTPM
cerebral cortex: 25 nTPM
amygdala: 25 nTPM
basal ganglia: 25 nTPM
hippocampal formation: 23 nTPM
white matter: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

DNA repair

Molecular functions

DNA binding
magnesium ion binding
RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
single-stranded RNA binding
DNA endonuclease activity, producing 5'-phosphomonoesters

Cellular components

Protein domainsUniProt · Pfam · InterPro

Endonuclease V
Endonuclease V

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENDOV in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PABPC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENDOV as an antibody target. Whether an autoantibody or antibody against ENDOV could matter depends on whether native ENDOV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENDOV is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENDOV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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