Seroatlas · Human Serome Atlas

ZFC3H1

Zinc finger C3H1 domain-containing protein

Also known as: CCDC131, CSRC2, KIAA0546, MGC23401, PSRC2, ZC3H1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60293
Gene: ZFC3H1
Ensembl: ENSG00000133858
Chromosome: 12
Canonical length: 1989 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of MTREC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1989 residues, UniProt reviewed canonical sequence.

>O60293|ZFC3H1
     1  MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS
    61  ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP
   121  SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA
   181  GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE
   241  CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
   301  LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK
   361  KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA
   421  KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN
   481  QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS
   541  SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
   601  LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN
   661  NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD
   721  GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL
   781  LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL
   841  MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
   901  QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE
   961  LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD
  1021  KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP
  1081  ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP
  1141  CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
  1201  WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ
  1261  MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE
  1321  NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS
  1381  ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF
  1441  LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
  1501  LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV
  1561  MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA
  1621  AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF
  1681  ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF
  1741  NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
  1801  NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL
  1861  ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG
  1921  QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN
  1981  SNKTESKNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFC3H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
lymph node: 14 nTPM
adrenal gland: 13 nTPM
blood vessel: 13 nTPM
retina: 12 nTPM
thymus: 12 nTPM

Single-cell type

neutrophils: 702 nCPM
neutrophil progenitors: 307 nCPM
epicardial cells: 298 nCPM
monocytes: 260 nCPM
urothelial cells: 254 nCPM
early spermatids: 203 nCPM

Immune cell

neutrophil: 61 nTPM
basophil: 61 nTPM
naive B-cell: 30 nTPM
eosinophil: 27 nTPM
plasmacytoid DC: 27 nTPM
memory B-cell: 22 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 24 nTPM
hypothalamus: 23 nTPM
white matter: 23 nTPM
thalamus: 22 nTPM
choroid plexus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFC3H1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 281 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.14
DepMap mean gene effect: -0.55
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA processing

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAT (Half-A-TPR) repeat
Tetratricopeptide-like helical domain superfamily
Putative zinc-finger domain
NURS complex subunit red1
Putative zinc-finger domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFC3H1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFC3H1 as an antibody target. Whether an autoantibody or antibody against ZFC3H1 could matter depends on whether native ZFC3H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFC3H1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFC3H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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