Seroatlas · Human Serome Atlas

TOB2

Protein Tob2

Also known as: APRO5, bK223H9, TOB2_HUMAN, TOB4, TOBL, TROB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14106
Gene: TOB2
Ensembl: ENSG00000183864
Chromosome: 22
Canonical length: 344 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q14106|TOB2
     1  MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL KGSGFRCVHI
    61  GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS YQIGEKGAVK VLYLDDSEGC
   121  GAPELDKEIK SSFNPDAQVF VPIGSQDSSL SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS
   181  FAATKFGSTK MKKGGGAASG GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL
   241  NFITANPAPQ SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD
   301  MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQQFQPV VLAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 86 nTPM
blood vessel: 81 nTPM
tongue: 64 nTPM
cerebellum: 57 nTPM
retina: 51 nTPM
adipose tissue: 43 nTPM

Single-cell type

myonuclei: 222 nCPM
epididymal basal cells: 216 nCPM
thymic myoid cells: 193 nCPM
ocular epithelial cells: 189 nCPM
enterocytes: 159 nCPM
rod photoreceptor cells: 155 nCPM

Immune cell

memory B-cell: 10 nTPM
non-classical monocyte: 8.5 nTPM
intermediate monocyte: 8 nTPM
plasmacytoid DC: 8 nTPM
gdT-cell: 7.6 nTPM
naive B-cell: 7.5 nTPM

Brain region

cerebellum: 168 nTPM
white matter: 149 nTPM
medulla oblongata: 137 nTPM
basal ganglia: 123 nTPM
thalamus: 114 nTPM
hypothalamus: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOB2 as an antibody target. Whether an autoantibody or antibody against TOB2 could matter depends on whether native TOB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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