Seroatlas · Human Serome Atlas

TENT2

Poly(A) RNA polymerase GLD2

Also known as: FLJ38499, GLD2, GLD2_HUMAN, PAPD4, TUT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PIY7
Gene
TENT2
Ensembl
ENSG00000164329
Chromosome
5
Canonical length
484 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables poly(A) RNA polymerase activity. Involved in histone mRNA catabolic process; mRNA 3'-end processing; and negative regulation of miRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>Q6PIY7|TENT2
     1  MFPNSILGRP PFTPNHQQHN NFFTLSPTVY SHQQLIDAQF NFQNADLSRA VSLQQLTYGN
    61  VSPIQTSASP LFRGRKRLSD EKNLPLDGKR QRFHSPHQEP TVVNQIVPLS GERRYSMPPL
   121  FHTHYVPDIV RCVPPFREIA FLEPREITLP EAKDKLSQQI LELFETCQQQ ISDLKKKELC
   181  RTQLQREIQL LFPQSRLFLV GSSLNGFGTR SSDGDLCLVV KEEPCFFQVN QKTEARHILT
   241  LVHKHFCTRL SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNIVGIRN TFLLRTYAYL
   301  ENRVRPLVLV IKKWASHHQI NDASRGTLSS YSLVLMVLHY LQTLPEPILP SLQKIYPESF
   361  SPAIQLHLVH QAPCNVPPYL SKNESNLGDL LLGFLKYYAT EFDWNSQMIS VREAKAIPRP
   421  DGIEWRNKYI CVEEPFDGTN TARAVHEKQK FDMIKDQFLK SWHRLKNKRD LNSILPVRAA
   481  VLKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 43 nTPM
  • lymph node: 30 nTPM
  • tonsil: 28 nTPM
  • spleen: 28 nTPM
  • thymus: 27 nTPM
  • breast: 25 nTPM

Single-cell type

  • choroid plexus epithelial cells: 469 nCPM
  • sertoli cells: 466 nCPM
  • neutrophil progenitors: 459 nCPM
  • myonuclei: 394 nCPM
  • microglia: 384 nCPM
  • podocytes: 344 nCPM

Immune cell

  • MAIT T-cell: 33 nTPM
  • basophil: 33 nTPM
  • non-classical monocyte: 28 nTPM
  • intermediate monocyte: 26 nTPM
  • T-reg: 25 nTPM
  • myeloid DC: 24 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • white matter: 29 nTPM
  • basal ganglia: 24 nTPM
  • medulla oblongata: 24 nTPM
  • cerebellum: 22 nTPM
  • thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TENT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENT2 as an antibody target. Whether an autoantibody or antibody against TENT2 could matter depends on whether native TENT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TENT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TENT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...