TENT5C
Terminal nucleotidyltransferase 5C
Also known as: FAM46C, FLJ20202, TET5C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VWP2
- Gene
- TENT5C
- Ensembl
- ENSG00000183508
- Chromosome
- 1
- Canonical length
- 391 aa
- Protein class
- Cancer-related genes, Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables poly(A) RNA polymerase activity. Involved in mRNA stabilization and negative regulation of cell differentiation. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
391 residues, UniProt reviewed canonical sequence.
>Q5VWP2|TENT5C
1 MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE
61 EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL
121 PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS
181 VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR
241 GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE
301 RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA
361 PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TENT5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 84 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 84 nTPM
- pancreas: 44 nTPM
- testis: 41 nTPM
- tonsil: 35 nTPM
- stomach: 29 nTPM
- skeletal muscle: 28 nTPM
Single-cell type
- late spermatids: 2,756 nCPM
- plasma cells: 738 nCPM
- early spermatids: 563 nCPM
- erythrocytes: 316 nCPM
- platelets: 251 nCPM
- t-cells: 232 nCPM
Immune cell
- basophil: 30 nTPM
- eosinophil: 16 nTPM
- T-reg: 14 nTPM
- memory B-cell: 13 nTPM
- naive B-cell: 10 nTPM
- memory CD8 T-cell: 4.4 nTPM
Brain region
- choroid plexus: 57 nTPM
- spinal cord: 4 nTPM
- medulla oblongata: 3.2 nTPM
- midbrain: 3.1 nTPM
- cerebral cortex: 2.9 nTPM
- hippocampal formation: 2.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.32
- gnomAD pLI
- 0.95
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TENT5C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TENT5C as an antibody target. Whether an autoantibody or antibody against TENT5C could matter depends on whether native TENT5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TENT5C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TENT5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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