Seroatlas · Human Serome Atlas

NFE2L2

Nuclear factor erythroid 2-related factor 2

Also known as: NF2L2_HUMAN, NRF-2, NRF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16236
Gene
NFE2L2
Ensembl
ENSG00000116044
Chromosome
2
Canonical length
605 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q16236|NFE2L2
     1  MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE
    61  QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM
   121  QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM
   181  QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG
   241  NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP
   301  SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS
   361  VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA
   421  QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD
   481  FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL
   541  KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP
   601  DVKKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFE2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
232 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 232 nTPM
  • liver: 159 nTPM
  • stomach: 152 nTPM
  • urinary bladder: 149 nTPM
  • ovary: 144 nTPM
  • skin: 132 nTPM

Single-cell type

  • neutrophils: 2,258 nCPM
  • renal connecting tubule cells: 1,877 nCPM
  • distal convoluted tubule cells: 911 nCPM
  • esophageal suprabasal cells: 828 nCPM
  • monocytes: 791 nCPM
  • suprabasal keratinocytes: 786 nCPM

Immune cell

  • basophil: 94 nTPM
  • neutrophil: 83 nTPM
  • myeloid DC: 79 nTPM
  • non-classical monocyte: 71 nTPM
  • naive CD4 T-cell: 70 nTPM
  • intermediate monocyte: 69 nTPM

Brain region

  • white matter: 127 nTPM
  • medulla oblongata: 122 nTPM
  • basal ganglia: 121 nTPM
  • choroid plexus: 115 nTPM
  • pons: 114 nTPM
  • midbrain: 112 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NFE2L2.

Disease | AllUniProt

Conditions NFE2L2 is implicated in, by any mechanism.

  • Immunodeficiency, developmental delay, and hypohomocysteinemia (IMDDHH) MIM:617744

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 427 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.21
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFE2L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFE2L2 as an antibody target. Whether an autoantibody or antibody against NFE2L2 could matter depends on whether native NFE2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFE2L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFE2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NFE2L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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