Seroatlas · Human Serome Atlas

CASP7

Caspase-7

Also known as: CASP7_HUMAN, CMH-1, ICE-LAP3, MCH3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55210
Gene
CASP7
Ensembl
ENSG00000165806
Chromosome
10
Canonical length
303 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>P55210|CASP7
     1  MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT TRDRVPTYQY
    61  NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC FRSLGFDVIV YNDCSCAKMQ
   121  DLLKKASEED HTNAACFACI LLSHGEENVI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL
   181  FFIQACRGTE LDDGIQADSG PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW
   241  FVQALCSILE EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY
   301  FSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • colon: 70 nTPM
  • small intestine: 64 nTPM
  • duodenum: 62 nTPM
  • rectum: 55 nTPM
  • stomach: 43 nTPM
  • salivary gland: 32 nTPM

Single-cell type

  • colonocytes: 161 nCPM
  • foveolar cells: 135 nCPM
  • enterocytes: 103 nCPM
  • goblet cells: 89 nCPM
  • pancreatic acinar cells: 70 nCPM
  • enteric transient amplifying cells: 52 nCPM

Immune cell

  • basophil: 23 nTPM
  • intermediate monocyte: 21 nTPM
  • non-classical monocyte: 19 nTPM
  • classical monocyte: 15 nTPM
  • memory CD8 T-cell: 14 nTPM
  • T-reg: 14 nTPM

Brain region

  • choroid plexus: 10 nTPM
  • thalamus: 10 nTPM
  • midbrain: 9.6 nTPM
  • white matter: 9.5 nTPM
  • medulla oblongata: 9.1 nTPM
  • hypothalamus: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CASP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CASP7 as an antibody target. Whether an autoantibody or antibody against CASP7 could matter depends on whether native CASP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CASP7 is annotated as secreted, so native CASP7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CASP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CASP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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