MAFF
Transcription factor MafF
Also known as: hMafF, MAFF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9ULX9
- Gene
- MAFF
- Ensembl
- ENSG00000185022
- Chromosome
- 22
- Canonical length
- 164 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Canonical amino-acid sequenceUniProt
164 residues, UniProt reviewed canonical sequence.
>Q9ULX9|MAFF
1 MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT RLKQRRRTLK
61 NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM RLELDALRGK CEALQGFARS
121 VAAARGPATL VAPASVITIV KSTPGSGSGP AHGPDPAHGP ASCSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAFF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 101 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 101 nTPM
- blood vessel: 81 nTPM
- skeletal muscle: 74 nTPM
- breast: 71 nTPM
- lung: 58 nTPM
- fallopian tube: 57 nTPM
Single-cell type
- endometrial glandular cells: 819 nCPM
- epididymal basal cells: 772 nCPM
- esophageal apical cells: 771 nCPM
- endometrial luminal cells: 688 nCPM
- syncytiotrophoblasts: 607 nCPM
- urothelial cells: 528 nCPM
Immune cell
- basophil: 24 nTPM
- NK-cell: 21 nTPM
- neutrophil: 8.6 nTPM
- non-classical monocyte: 3.6 nTPM
- gdT-cell: 2.8 nTPM
- MAIT T-cell: 2.8 nTPM
Brain region
- white matter: 26 nTPM
- medulla oblongata: 23 nTPM
- thalamus: 23 nTPM
- pons: 21 nTPM
- hypothalamus: 18 nTPM
- cerebral cortex: 16 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MAFF.
Disease | ImmuneIEDB
Conditions an epitope on MAFF was assayed in.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.7
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- in utero embryonic development
- negative regulation of transcription by RNA polymerase II
- parturition
- positive regulation of transcription by RNA polymerase II
- regulation of epidermal cell differentiation
- regulation of transcription by RNA polymerase II
- skeletal muscle cell differentiation
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MAFF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAFF as an antibody target. Whether an autoantibody or antibody against MAFF could matter depends on whether native MAFF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAFF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MAFF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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