Seroatlas · Human Serome Atlas

MAFG

Transcription factor MafG

Also known as: MAFG_HUMAN, MGC13090, MGC20149

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15525
Gene: MAFG
Ensembl: ENSG00000197063
Chromosome: 17
Canonical length: 162 aa
Protein class: Predicted intracellular proteins, Transcription factors
Quaternary structure: Homodimer

OverviewNCBI Gene

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>O15525|MAFG
     1  MTTPNKGNKA LKVKREPGEN GTSLTDEELV TMSVRELNQH LRGLSKEEIV QLKQRRRTLK
    61  NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KLELDALRSK YEALQTFART
   121  VARSPVAPAR GPLAAGLGPL VPGKVAATSV ITIVKSKTDA RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAFG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 42 nTPM
bone marrow: 38 nTPM
cerebral cortex: 23 nTPM
lung: 21 nTPM
tongue: 18 nTPM
amygdala: 18 nTPM

Single-cell type

late spermatids: 163 nCPM
early spermatids: 92 nCPM
platelets: 92 nCPM
breast secretory cells: 86 nCPM
megakaryocytes: 80 nCPM
epididymal basal cells: 69 nCPM

Immune cell

basophil: 12 nTPM
neutrophil: 3.2 nTPM
classical monocyte: 2.8 nTPM
myeloid DC: 2.3 nTPM
plasmacytoid DC: 1.7 nTPM
eosinophil: 1.5 nTPM

Brain region

pons: 65 nTPM
midbrain: 54 nTPM
medulla oblongata: 50 nTPM
hypothalamus: 50 nTPM
thalamus: 49 nTPM
cerebral cortex: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.73
gnomAD missense Z: 2.08
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAFG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAFG as an antibody target. Whether an autoantibody or antibody against MAFG could matter depends on whether native MAFG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAFG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAFG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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